Compatibility «Spironolactone» and «Torasemide»
Between «Spironolactone» and «Torasemide» found 4 dangerous and 8 negative interactions, joint admission is not recommended without consulting a doctor.
Interaction tableCompare |
Torasemide |
✘Spironolactone Analogs | |
✘Torasemide Analogs |
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Interactions Spironolactone with Torasemide
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Dangerous interactions
Lithium-containing drugs, as a rule, should not be prescribed with diuretics. Diuretics reduce the renal clearance of lithium, increasing its concentration in blood plasma and the risk of its toxicity. Diuretics reduce the renal clearance of lithium and increase the risk of developing toxic effects of lithium preparations. Like other diuretics, torasemide reduces the renal clearance of lithium, causing a high risk of lithium intoxication. -
Negative interactions
In some patients, NSAIDs may reduce the diuretic, natriuretic and antihypertensive effects of loop, potassium-sparing and thiazide diuretics. Therefore, with the simultaneous use of spironolactone and NSAIDs, it is necessary to closely monitor the patient to determine whether the desired effect of the diuretic is achieved. Antihypertensive drugs: spironolactone potentiates the effect of antihypertensive drugs, the dose of which, when taken simultaneously with spironolactone, may need to be reduced and adjusted further if necessary. Nonsteroidal anti-inflammatory drugs (NSAIDs): In some patients, NSAIDs may reduce the diuretic, natriuretic and antihypertensive effects of loop, potassium-sparing and thiazide diuretics. Thus, while taking spironolactone with NSAIDs, the patient's condition should be carefully monitored to achieve the desired effect of the diuretic drug. Lithium preparations: as a rule, lithium preparations should not be used in conjunction with diuretics. Carbamazepine: when used concomitantly with diuretics, the drug may cause clinically significant hyponatremia. In healthy volunteers, the combined use of torasemide was associated with a significant decrease in renal clearance of spironolactone with a corresponding increase in AUC. -
Positive interactions
Simultaneous use of other diuretics: increased diuresis. -
Unclear interactions
Spironolactone. However, spironolactone does not alter the pharmacokinetic profile and diuretic activity of torasemide.
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Dangerous interactions
Decoding the colors of interactions and contraindications
Dangerous | — | a pronounced negative interaction or contraindication. |
Negative | — | negative interaction or side effect that may reduce effectiveness. |
Positive | — | the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug. |
No | — | the drugs do NOT interact, which is separately indicated in the instructions. |
Unclear | — | the system failed to pre-assess the danger. |
Video instruction
Additional information
- Kiberis checks interactions and evaluates drug compatibility online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
- Why do I need to
- Avoid dangerous prescriptions for your patients.
- Check the contraindications.
- Evaluate the safety of therapy in the treatment of children.
- See the compatibility of drugs with alcohol (enter it as a drug).
- Point the doctor to the found interaction - you may need to adjust the therapy.
- The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
- The article is written: artificial intelligence Kiberis
- Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
- Total analyzed: 169,974,420 possible combinations of drugs and their components were found 412,510 interacting combinations.
- Medicine section: Standard evidence-based medicine
- The date of the last update of the interaction database: 2024-05-02
Category - medicine