Compatibility «Quetiapine» and «Irunin»
Between «Quetiapine» and «Irunin» found 11 negative interactions, they should be taken with caution. the doctor may need to adjust the dosage.
Interaction tableCompare |
Irunin |
✘Quetiapine Analogs | |
✘Irunin [Itraconazole] Analogs |
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Interactions Quetiapine with Irunin
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Negative interactions
Quetiapine exposure is increased by inhibitors of the CYP3A4 isoenzyme (e.g. ketoconazole, itraconazole, indinavir, ritonavir, nefazodone, etc. ) and is reduced by inducers of the CYP3A4 isoenzyme (for example, phenytoin, carbamazepine, rifampicin, avazimib, drugs containing St. John's wort). Dose adjustment of quetiapine is required if it is used simultaneously with strong inducers or inhibitors of CYP3A4. Inhibitors of the CYP3A4 isoenzyme. The combined use of ketoconazole, a strong cytochrome CYP3A4 inhibitor, led to a significant increase in quetiapine exposure. The dose of quetiapine should be reduced to one sixth of the initial dose when used in combination with strong CYP3A4 inhibitors (see 'Dosage and administration', 'Pharmacology'). The combined use of quetiapine and phenytoin, an inducer of the CYP3A4 isoenzyme, increased the average oral clearance of quetiapine by 5 times. It may be necessary to increase the dose of quetiapine up to 5 times to maintain control over the symptoms of schizophrenia in patients receiving quetiapine and phenytoin together or other known strong inducers of the CYP3A4 isoenzyme (see 'Dosage and administration', 'Pharmacology'). Upon discontinuation of the combined use of the CYP3A4 isoenzyme inducer, the dose of quetiapine should be reduced to the initial level within 7-14 days (see 'Method of administration and doses'). Quetiapine and its metabolites are not inhibitors of the main metabolizing isoenzymes CYP1A2, CYP2C9, CYP2C19, CYP2D6 and CYP3A4. Use with caution, monitor for adverse reactions to antipsychotics, anxiolytics or sleeping pills with , it may be necessary to reduce the doses of these drugs. -
Unclear interactions
Inducers of the CYP3A4 isoenzyme. Ketoconazole (a strong CYP3A4 inhibitor). In vitro enzyme inhibition data suggest that quetiapine and 9 of its metabolites will have a weak inhibitory effect on in vivo metabolism mediated by the isoenzymes CYP1A2, CYP2C9, CYP2C19, CYP2D6 and CYP3A4. Antipsychotics, anxiolytics and hypnotics. Quetiapine. Quetiapine max'>Cmax (↑↑), AUC (↑↑↑)a.
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Negative interactions
Decoding the colors of interactions and contraindications
Dangerous | — | a pronounced negative interaction or contraindication. |
Negative | — | negative interaction or side effect that may reduce effectiveness. |
Positive | — | the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug. |
No | — | the drugs do NOT interact, which is separately indicated in the instructions. |
Unclear | — | the system failed to pre-assess the danger. |
Video instruction
Additional information
- Kiberis checks interactions and evaluates drug compatibility online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
- Why do I need to
- Avoid dangerous prescriptions for your patients.
- Check the contraindications.
- Evaluate the safety of therapy in the treatment of children.
- See the compatibility of drugs with alcohol (enter it as a drug).
- Point the doctor to the found interaction - you may need to adjust the therapy.
- The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
- The article is written: artificial intelligence Kiberis
- Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
- Total analyzed: 169,974,420 possible combinations of drugs and their components were found 412,510 interacting combinations.
- Medicine section: Standard evidence-based medicine
- The date of the last update of the interaction database: 2024-05-02
Category - medicine