Compatibility «Nifedipine» and «Dexamethasone»
Between «Nifedipine» and «Dexamethasone» found 1 dangerous and 9 negative interactions, joint admission is not recommended without consulting a doctor.
Interaction tableCompare |
Dexamethasone |
✘Nifedipine Analogs | |
✘Dexamethasone Analogs |
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Interactions Nifedipine with Dexamethasone
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Dangerous interactions
Calcium channel blockers(C08) + Drugs that cause hypokalemia; Glucocorticosteroids (C03A, A01AB04,J02AA01,H02,D07 => Increases the likelihood of ventricular tachycardia and ventricular fibrillation. (A dangerous combination, it is necessary to eliminate hypokalemia before use). -
Negative interactions
Rifampicin is a powerful inducer of the CYP3A4 isoenzyme. It is known that some macrolides inhibit the CYP3A4 isoenzyme. Azithromycin, which belongs to the macrolide group of antibiotics, does not inhibit the CYP3A4 isoenzyme. It is known that drugs of this class inhibit the CYP3A4 isoenzyme. It was found that cimetidine and ranitidine inhibit the CYP3A4 isoenzyme and cause an increase in the concentration of nifedipine in blood plasma (by 80% and 70%, respectively), thereby enhancing its antihypertensive effect. Fluoxetine is known to inhibit in vitro nifedipine metabolism mediated by the action of the CYP3A4 isoenzyme. Nefazodone is known to inhibit the metabolism of other drugs mediated by the action of the CYP3A4 isoenzyme. Grapefruit juice inhibits the CYP3A4 isoenzyme and inhibits the metabolism of nifedipine. Substrates of the CYP3A4 isoenzyme (e.g., cisapride, tacrolimus, benzodiazepines, imipramine, propafenone, terfenadine, warfarin) when used concomitantly with nifedipine, they can act as CYP3A4 inhibitors and increase the concentration of nifedipine in blood plasma. -
Unclear interactions
Antiepileptic drugs that induce the CYP3A4 isoenzyme (for example, phenytoin, carbamazepine, phenobarbital). Phenytoin induces the CYP3A4 isoenzyme. Tacrolimus is metabolized with the participation of the CYP3A4 isoenzyme.
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Dangerous interactions
Decoding the colors of interactions and contraindications
Dangerous | — | a pronounced negative interaction or contraindication. |
Negative | — | negative interaction or side effect that may reduce effectiveness. |
Positive | — | the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug. |
No | — | the drugs do NOT interact, which is separately indicated in the instructions. |
Unclear | — | the system failed to pre-assess the danger. |
Video instruction
Additional information
- Kiberis checks interactions and evaluates drug compatibility online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
- Why do I need to
- Avoid dangerous prescriptions for your patients.
- Check the contraindications.
- Evaluate the safety of therapy in the treatment of children.
- See the compatibility of drugs with alcohol (enter it as a drug).
- Point the doctor to the found interaction - you may need to adjust the therapy.
- The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
- The article is written: artificial intelligence Kiberis
- Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
- Total analyzed: 169,974,420 possible combinations of drugs and their components were found 412,510 interacting combinations.
- Medicine section: Standard evidence-based medicine
- The date of the last update of the interaction database: 2024-05-02
Category - medicine