Compatibility «Nifedipine» and «Sotalol»
Between «Nifedipine» and «Sotalol» found 4 dangerous and 4 negative interactions, joint admission is not recommended without consulting a doctor.
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Interactions Nifedipine with Sotalol
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Dangerous interactions
With the simultaneous use of nifedipine and beta-blockers, it is necessary to carefully monitor the patient's condition, since in some cases it is possible to aggravate the course of chronic heart failure. Calcium channel blockers (C08,C08CA) + Class I and III antiarrhythmic drugs (C01B) => Significantly increases the likelihood of ventricular fibrillation. (The combination should be avoided). Simultaneous administration of beta-blockers and blockers of 'slow' calcium channels can lead to arterial hypotension, bradycardia, impaired conduction and heart failure. beta-blockers (C07) + Verapamil, reserpine, phenigidine => Increased existing heart failure, bradycardia, impaired conduction. -
Negative interactions
The antihypertensive effect of nifedipine may be enhanced when used concomitantly with antihypertensive drugs such as diuretics, beta-blockers, angiotensin converting enzyme (ACE) inhibitors, angiotensin II receptor antagonists (ARA II), other BMCC, alpha-blockers, phosphodiesterase‑5 inhibitors, methyldopa. BMCC can enhance the negative inotropic effect of antiarrhythmic drugs such as amiodarone and quinidine. Cardiac glycosides, reserpine, clonidine, alpha-methyldofa, guanfacine potentiate heart rate reduction and inhibition of intracardiac conduction, calcium antagonists block beta-adrenergic receptors, amiodarone - the risk of arrhythmias. Simultaneous use of beta-blockers and blockers of 'slow' calcium channels that suppress myocardial function (for example, verapamil and diltiazem) should be avoided due to the additive effect of these agents on atrioventricular conduction and ventricular function. -
Positive interactions
Nitrates, beta-blockers, diuretics, tricyclic antidepressants, fentanyl, alcohol - enhance the hypotensive effect. -
Unclear interactions
Antiarrhythmic drugs. Blockers of 'slow' calcium channels.
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Dangerous interactions
Decoding the colors of interactions and contraindications
Dangerous | — | a pronounced negative interaction or contraindication. |
Negative | — | negative interaction or side effect that may reduce effectiveness. |
Positive | — | the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug. |
No | — | the drugs do NOT interact, which is separately indicated in the instructions. |
Unclear | — | the system failed to pre-assess the danger. |
Video instruction
Additional information
- Kiberis checks interactions and evaluates drug compatibility online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
- Why do I need to
- Avoid dangerous prescriptions for your patients.
- Check the contraindications.
- Evaluate the safety of therapy in the treatment of children.
- See the compatibility of drugs with alcohol (enter it as a drug).
- Point the doctor to the found interaction - you may need to adjust the therapy.
- The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
- The article is written: artificial intelligence Kiberis
- Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
- Total analyzed: 169,974,420 possible combinations of drugs and their components were found 412,510 interacting combinations.
- Medicine section: Standard evidence-based medicine
- The date of the last update of the interaction database: 2024-05-02
Category - medicine