Compatibility «Rifampicin» and «Raltegravir»
Between «Rifampicin» and «Raltegravir» found 1 dangerous and 3 negative interactions, joint admission is not recommended without consulting a doctor.
Interaction tableCompare |
Raltegravir |
✘Rifampicin Analogs | |
✘Raltegravir Analogs |
-
Interactions Rifampicin with Raltegravir
-
Dangerous interactions
Concomitant use with HIV protease inhibitors (indinavir, nelfinavir, atazanavir, darunavir, fosamprenavir, saquinavir and tipranavir, amprenavir, lopinavir) should be avoided. -
Negative interactions
Caution should be exercised when using raltegravir concomitantly with strong inducers of UDP-GT1A1 (e.g. rifampicin), given that raltegravir is metabolized mainly by UDP-GT1A1. Rifampicin reduces the concentration of raltegravir in blood plasma. If combination therapy with rifampicin cannot be avoided, it is necessary to consider increasing the dose of raltegravir by 2 times. -
No interactions
However, if concomitant use with rifampicin cannot be avoided, the dose of raltegravir in adults can be doubled. There are no data on the simultaneous use of raltegravir and rifampicin in patients under 18 years of age. -
Unclear interactions
Rifampicin (anti-tuberculosis agent)(raltegravir 400 mg 1 time per day).
-
Dangerous interactions
Decoding the colors of interactions and contraindications
Dangerous | — | a pronounced negative interaction or contraindication. |
Negative | — | negative interaction or side effect that may reduce effectiveness. |
Positive | — | the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug. |
No | — | the drugs do NOT interact, which is separately indicated in the instructions. |
Unclear | — | the system failed to pre-assess the danger. |
Video instruction
Additional information
- Kiberis checks interactions and evaluates drug compatibility online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
- Why do I need to
- Avoid dangerous prescriptions for your patients.
- Check the contraindications.
- Evaluate the safety of therapy in the treatment of children.
- See the compatibility of drugs with alcohol (enter it as a drug).
- Point the doctor to the found interaction - you may need to adjust the therapy.
- The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
- The article is written: artificial intelligence Kiberis
- Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
- Total analyzed: 169,972,605 possible combinations of drugs and their components were found 412,508 interacting combinations.
- Medicine section: Standard evidence-based medicine
- The date of the last update of the interaction database: 2024-04-11
Category - medicine