Compatibility «Ethinylestradiol» and «Etoricoxib»
Between «Ethinylestradiol» and «Etoricoxib» found 1 dangerous and 4 negative interactions, joint admission is not recommended without consulting a doctor.
Interaction tableCompare |
Etoricoxib |
✘Ethinylestradiol Analogs | |
✘Etoricoxib Analogs |
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Interactions Ethinylestradiol with Etoricoxib
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Dangerous interactions
This increase in the concentration of estrogens should be taken into account when choosing postmenopausal hormone therapy when used in combination with etoricoxib, since increased exposure to estrogens may increase the risk of adverse reactions associated with HRT. -
Negative interactions
This increase in the concentration of ethinyl estradiol should be taken into account when choosing an oral contraceptive for combined use with etoricoxib. Increased exposure to ethinyl estradiol may increase the frequency of adverse reactions associated with oral contraceptives (for example, venous thromboembolic events in women at risk). The effect of etoricoxib at a dose of 120 mg on the AUC0-24 of these estrogenic components of premarin was more than 2 times less than that observed when taking premarin alone and increasing the dose from 0.625 to 1.25 mg. Etoricoxib is an inhibitor of the activity of human sulfotransferases, in particular SULT1E1, and has been shown to increase the concentration of ethinyl estradiol in blood serum. -
No interactions
Simultaneous use of etoricoxib at a dose of 60 mg and an oral contraceptive (35 mcg ethinyl estradiol and 0.5-1 mg norethindrone) for 21 days increased the AUC0-24 ethinyl estradiol by 37%. Etoricoxib at a dose of 120 mg, taken with the same oral contraceptive simultaneously or with a difference of 12 hours, increased the AUC0-24 ethinyl estradiol by 50-60%. Simultaneous use of etoricoxib for 28 days at a dose of 120 mg and HRT consisting of conjugated estrogens (0.625 mg premarin) increased the mean equilibrium AUC0-24 of unconjugated estrone (41%), equilin (76%) and 17-β-estradiol (22%).
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Dangerous interactions
Decoding the colors of interactions and contraindications
Dangerous | — | a pronounced negative interaction or contraindication. |
Negative | — | negative interaction or side effect that may reduce effectiveness. |
Positive | — | the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug. |
No | — | the drugs do NOT interact, which is separately indicated in the instructions. |
Unclear | — | the system failed to pre-assess the danger. |
Video instruction
Additional information
- Kiberis checks interactions and evaluates drug compatibility online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
- Why do I need to
- Avoid dangerous prescriptions for your patients.
- Check the contraindications.
- Evaluate the safety of therapy in the treatment of children.
- See the compatibility of drugs with alcohol (enter it as a drug).
- Point the doctor to the found interaction - you may need to adjust the therapy.
- The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
- The article is written: artificial intelligence Kiberis
- Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
- Total analyzed: 169,974,420 possible combinations of drugs and their components were found 412,510 interacting combinations.
- Medicine section: Standard evidence-based medicine
- The date of the last update of the interaction database: 2024-05-02
Category - medicine