Compatibility «Metformin» and «Glimepiride»
Between «Metformin» and «Glimepiride» found 1 dangerous and 5 negative interactions, joint admission is not recommended without consulting a doctor.
Interaction tableCompare |
Glimepiride |
✘Metformin Analogs | |
✘Glimepiride Analogs |
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Interactions Metformin with Glimepiride
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Dangerous interactions
A number of drugs affect glucose metabolism, and it may be necessary to adjust the dose of glimepiride and especially careful monitoring of hypoglycemia or deterioration of glycemic control. -
Negative interactions
Discontinuation of such drugs in patients receiving metformin requires careful monitoring of their condition due to the possibility of hypoglycemia. The following are examples of drugs that can enhance the glucose-lowering effect of sulfonylurea derivatives, including glimepiride, increasing the predisposition and/or intensity of hypoglycemia: oral hypoglycemic agents, pramlintide acetate, insulin, ACE inhibitors, H2-antihistamines, fibrates, propoxyphene, pentoxifylline, somatostatin analogues, anabolic steroids and androgens, cyclophosphamide, pheniramidol, guanethidine, fluconazole, sulfinpyrazone, tetracyclines, clarithromycin, disopyramide, quinolones and drugs with a high degree of protein binding, such as fluoxetine, NSAIDs, salicylates, sulfonamides, chloramphenicol, coumarins, probenecid and MAO inhibitors. When prescribing these drugs to a patient taking glimepiride, careful monitoring of the patient's condition for the development of hypoglycemia is necessary. When canceling these drugs in a patient taking glimepiride, careful monitoring of the condition for the development of hypoglycemia is necessary. Signs of hypoglycemia may be attenuated or absent in patients taking sympatholytics such as beta-blockers, clonidine, guanethidine and reserpine. -
Unclear interactions
Metformin + Glimepiride analgin and citramon are used together in Amaryl M, Глидика М.
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Dangerous interactions
Decoding the colors of interactions and contraindications
Dangerous | — | a pronounced negative interaction or contraindication. |
Negative | — | negative interaction or side effect that may reduce effectiveness. |
Positive | — | the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug. |
No | — | the drugs do NOT interact, which is separately indicated in the instructions. |
Unclear | — | the system failed to pre-assess the danger. |
Video instruction
Additional information
- Kiberis checks interactions and evaluates drug compatibility online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
- Why do I need to
- Avoid dangerous prescriptions for your patients.
- Check the contraindications.
- Evaluate the safety of therapy in the treatment of children.
- See the compatibility of drugs with alcohol (enter it as a drug).
- Point the doctor to the found interaction - you may need to adjust the therapy.
- The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
- The article is written: artificial intelligence Kiberis
- Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
- Total analyzed: 169,974,420 possible combinations of drugs and their components were found 412,510 interacting combinations.
- Medicine section: Standard evidence-based medicine
- The date of the last update of the interaction database: 2024-05-02
Category - medicine