Compatibility «Omeprazole» and «Dabigatran etexilate»
Between «Omeprazole» and «Dabigatran etexilate» found 2 dangerous and 2 negative interactions, joint admission is not recommended without consulting a doctor.
Interaction tableCompare |
Dabigatran etexilate |
✘Omeprazole Analogs | |
✘Dabigatran etexilate Analogs |
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Interactions Omeprazole with Dabigatran etexilate
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Dangerous interactions
It was found that the simultaneous use of proton pump inhibitors is not accompanied by a decrease in the concentration of dabigatran and, on average, only slightly reduces its concentration in blood plasma (by 11%). Pantoprazole and other proton pump inhibitors have been used in conjunction with dabigatran etexilate in clinical studies, with no effect on bleeding risk or efficacy. -
Negative interactions
The changes in the pharmacokinetic parameters of dabigatran revealed during the population analysis under the influence of proton pump inhibitors and antacids turned out to be clinically insignificant, since the severity of these changes was small (the decrease in bioavailability was not significant when prescribing antacids, and when using proton pump inhibitors was 14.6%). Therefore, the simultaneous use of proton pump inhibitors does not seem to lead to an increase in the incidence of stroke or systemic thromboembolism, especially in comparison with warfarin, and, consequently, the decrease in the bioavailability of dabigatran caused by the simultaneous use of pantoprazole probably has no clinical significance.
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Dangerous interactions
Decoding the colors of interactions and contraindications
Dangerous | — | a pronounced negative interaction or contraindication. |
Negative | — | negative interaction or side effect that may reduce effectiveness. |
Positive | — | the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug. |
No | — | the drugs do NOT interact, which is separately indicated in the instructions. |
Unclear | — | the system failed to pre-assess the danger. |
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Additional information
- Kiberis checks interactions and evaluates drug compatibility online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
- Why do I need to
- Avoid dangerous prescriptions for your patients.
- Check the contraindications.
- Evaluate the safety of therapy in the treatment of children.
- See the compatibility of drugs with alcohol (enter it as a drug).
- Point the doctor to the found interaction - you may need to adjust the therapy.
- The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
- The article is written: artificial intelligence Kiberis
- Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
- Total analyzed: 169,974,420 possible combinations of drugs and their components were found 412,510 interacting combinations.
- Medicine section: Standard evidence-based medicine
- The date of the last update of the interaction database: 2024-05-02
Category - medicine