Compatibility «Amlodipine» and «Simvastatin»
Between «Amlodipine» and «Simvastatin» found 4 negative interactions, they should be taken with caution. the doctor may need to adjust the dosage.
Interaction tableCompare |
Simvastatin |
✘Amlodipine Analogs | |
✘Simvastatin Analogs |
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Interactions Amlodipine with Simvastatin
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Negative interactions
The combined use of simvastatin with amlodipine increases the systemic exposure of simvastatin. The combined use of several doses of amlodipine 10 mg with 80 mg of simvastatin led to an increase in simvastatin exposure by 77% compared with taking simvastatin alone. Simultaneous repeated use of amlodipine at a dose of 10 mg and simvastatin at a dose of 80 mg leads to an increase in simvastatin exposure by 77%. simultaneous use of amlodipine and simvastatin shows an increase in AUC and. -
No interactions
simultaneous use of amlodipine and simvastatin at a dose of 80 mg is available. -
Unclear interactions
Simvastatin. It is necessary to reduce the dose of simvastatin in patients receiving amlodipine at a dose of up to 20 mg per day. In such cases, the dose of simvastatin should be limited to 20 mg. Amlodipine.
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Negative interactions
Decoding the colors of interactions and contraindications
Dangerous | — | a pronounced negative interaction or contraindication. |
Negative | — | negative interaction or side effect that may reduce effectiveness. |
Positive | — | the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug. |
No | — | the drugs do NOT interact, which is separately indicated in the instructions. |
Unclear | — | the system failed to pre-assess the danger. |
Video instruction
Additional information
- Kiberis checks interactions and evaluates drug compatibility online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
- Why do I need to
- Avoid dangerous prescriptions for your patients.
- Check the contraindications.
- Evaluate the safety of therapy in the treatment of children.
- See the compatibility of drugs with alcohol (enter it as a drug).
- Point the doctor to the found interaction - you may need to adjust the therapy.
- The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
- The article is written: artificial intelligence Kiberis
- Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
- Total analyzed: 169,974,420 possible combinations of drugs and their components were found 412,510 interacting combinations.
- Medicine section: Standard evidence-based medicine
- The date of the last update of the interaction database: 2024-05-02
Category - medicine