Compatibility «Folic acid» and «Methotrexate»
Between «Folic acid» and «Methotrexate» found 7 negative and 1 positive interaction, they should be taken with caution. the doctor may need to adjust the dosage.
Interaction tableCompare |
Methotrexate |
✘Folic acid Analogs | |
✘Methotrexate Analogs |
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Interactions Folic acid with Methotrexate
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Negative interactions
Combined use with analgesics, anticonvulsants, antacids, colestyramine, sulfonamides, antibiotics, cytostatics reduces the effect. Methotrexate, pyrimethamine, triamterene, trimethoprim inhibit dihydrofolate reductase and reduce the effect of folic acid (instead, patients using these drugs should be prescribed calcium folinate). Simultaneous use of triamterene and methotrexate causes inhibition of bone marrow function and folic acid (folate) deficiency. Vitamin preparations containing folic acid or its derivatives may reduce the effectiveness of methotrexate. In patients with rheumatoid arthritis or psoriasis, folic acid or folinic acid can reduce the side effects of methotrexate, in pm gastrointestinal symptoms, stomatitis, alopecia and increased levels of liver enzymes. Before taking additional folic acid, it is recommended to check the level of vitamin B12, especially in adult patients over 50 years of age, since taking folic acid can mask the symptoms of vitamin B deficiency12. Folic acid deficiency may increase the toxicity of methotrexate. -
Positive interactions
The increased and prolonged effect of methotrexate, leading to intoxication, is facilitated by the simultaneous use of NSAIDs, barbiturates, sulfonamides, corticosteroids, tetracyclines, trimethoprim, chloramphenicol, paraaminobenzoic and paraaminohippuric acids, probenecid. -
Unclear interactions
Folic acid and its derivatives reduce the effectiveness.
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Negative interactions
Decoding the colors of interactions and contraindications
Dangerous | — | a pronounced negative interaction or contraindication. |
Negative | — | negative interaction or side effect that may reduce effectiveness. |
Positive | — | the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug. |
No | — | the drugs do NOT interact, which is separately indicated in the instructions. |
Unclear | — | the system failed to pre-assess the danger. |
Video instruction
Additional information
- Kiberis checks interactions and evaluates drug compatibility online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
- Why do I need to
- Avoid dangerous prescriptions for your patients.
- Check the contraindications.
- Evaluate the safety of therapy in the treatment of children.
- See the compatibility of drugs with alcohol (enter it as a drug).
- Point the doctor to the found interaction - you may need to adjust the therapy.
- The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
- The article is written: artificial intelligence Kiberis
- Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
- Total analyzed: 169,972,605 possible combinations of drugs and their components were found 412,508 interacting combinations.
- Medicine section: Standard evidence-based medicine
- The date of the last update of the interaction database: 2024-04-11
Category - medicine