Compatibility «Fentanyl» and «Clarithromycin»
Between «Fentanyl» and «Clarithromycin» found 1 dangerous and 8 negative interactions, joint admission is not recommended without consulting a doctor.
Interaction tableCompare |
Clarithromycin |
✘Fentanyl Analogs | |
✘Clarithromycin Analogs |
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Interactions Fentanyl with Clarithromycin
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Dangerous interactions
After discontinuation of CYP3A4 inducers, their effects pass gradually, which can cause prolongation of the therapeutic and side effects of fentanyl and severe respiratory depression. -
Negative interactions
Fentanyl has a high clearance, it is rapidly and largely metabolized, mainly by cytochrome CYP3A4. Simultaneous use of a transdermal patch with fentanyl and cytochrome P450 3A4 (CYP3A4) inhibitors (in pm ritonavir, ketoconazole, itraconazole, fluconazole, voriconazole, clarithromycin, erythromycin, nelfinavir, nefazodone, verapamil, diltiazem, cimetidine, amiodarone) may lead to an increase in the concentration of fentanyl in blood plasma. Patients should take a break for at least 48 hours between discontinuation of cytochrome P450 3A4 (CYP3A4) inhibitors and the first application of the drug Fendivia. It is assumed that the degree of interaction with strong CYP3A4 inhibitors will be higher compared to weak or moderate CYP3A4 inhibitors. After the combined use of weak, moderate or strong CYP3A4 inhibitors with short-acting forms of fentanyl, the decrease in the rate of fentanyl elimination, as a rule, did not exceed 25%. Simultaneous use of a transdermal patch with fentanyl and CYP3A4 inducers (in pm rifampicin, carbamazepine, phenobarbital, phenytoin) may lead to a decrease in the concentration of fentanyl in blood plasma and a decrease in therapeutic effect. Caution should be exercised when using CYP3A4 inducers and the drug Fendivia at the same time. The planned withdrawal of concomitant therapy with a CYP3A4 inducer will require a reduction in the dose of fentanyl and careful monitoring of the patient. -
No interactions
Simultaneous use of a transdermal patch with fentanyl and CYP3A4 inhibitors is not recommended. The degree of interaction of CYP3A4 inhibitors when using transdermal patches with fentanyl is unknown, but it may be more pronounced compared to short-acting forms of fentanyl when administered. -
Unclear interactions
CYP3A4 inhibitors. However, when taken with ritonavir (a strong CYP3A4 inhibitor), the rate of fentanyl elimination decreased by an average of 67%. CYP3A4 inducers.
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Dangerous interactions
Decoding the colors of interactions and contraindications
Dangerous | — | a pronounced negative interaction or contraindication. |
Negative | — | negative interaction or side effect that may reduce effectiveness. |
Positive | — | the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug. |
No | — | the drugs do NOT interact, which is separately indicated in the instructions. |
Unclear | — | the system failed to pre-assess the danger. |
Video instruction
Additional information
- Kiberis checks interactions and evaluates drug compatibility online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
- Why do I need to
- Avoid dangerous prescriptions for your patients.
- Check the contraindications.
- Evaluate the safety of therapy in the treatment of children.
- See the compatibility of drugs with alcohol (enter it as a drug).
- Point the doctor to the found interaction - you may need to adjust the therapy.
- The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
- The article is written: artificial intelligence Kiberis
- Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
- Total analyzed: 169,974,420 possible combinations of drugs and their components were found 412,510 interacting combinations.
- Medicine section: Standard evidence-based medicine
- The date of the last update of the interaction database: 2024-05-02
Category - medicine