Compatibility «Carbamazepine» and «Lamotrigine»
Between «Carbamazepine» and «Lamotrigine» found 2 dangerous and 2 negative interactions, joint admission is not recommended without consulting a doctor.
Interaction tableCompare |
Lamotrigine |
✘Carbamazepine Analogs | |
✘Lamotrigine Analogs |
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Interactions Carbamazepine with Lamotrigine
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Dangerous interactions
Taking lamotrigine has no noticeable effect on ss'>Css carbamazepine in blood plasma. In a small group of patients (n=7) who participated in a placebo-controlled study, lamotrigine intake did not affect the concentration of carbamazepine epoxide in blood plasma, but in a small uncontrolled study (n=9) the concentration of carbamazepine epoxide increased. -
Negative interactions
A gradual transient increase in the concentration of lamotrigine in blood plasma (approximately a 2-fold increase) occurred during a week without pills in women who also did not take drugs that increase lamotrigine clearance (carbamazepine, phenytoin, phenobarbital, primidone or other drugs such as rifampicin and protease inhibitors lopinavir + ritonavir and atazanavir + ritonavir, inducing glucuronidation of lamotrigine). Limited clinical data indicate a higher incidence of dizziness, diplopia, ataxia and blurred vision in patients receiving carbamazepine and lamotrigine together than in patients receiving other antiepileptic drugs with lamotrigine. -
Unclear interactions
- antiepileptic drugs: clobazam, clonazepam, ethosuximide, felbamate, lamotrigine, eslicarbazepine, oxcarbazepine, primidone, thiagabine, topiramate, valproic acid, zonisamide. Carbamazepine. Carbamazepine epoxide7. Valproate + phenytoin and/or carbamazepine. 7 It is not prescribed, but is an active metabolite of carbamazepine. The effect of lamotrigine on the concentration of carbamazepine epoxide in blood plasma has not been clarified. Concomitant use of carbamazepine reduces ss'>Css lamotrigine by about 40%.
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Dangerous interactions
Decoding the colors of interactions and contraindications
Dangerous | — | a pronounced negative interaction or contraindication. |
Negative | — | negative interaction or side effect that may reduce effectiveness. |
Positive | — | the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug. |
No | — | the drugs do NOT interact, which is separately indicated in the instructions. |
Unclear | — | the system failed to pre-assess the danger. |
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Additional information
- Kiberis checks interactions and evaluates drug compatibility online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
- Why do I need to
- Avoid dangerous prescriptions for your patients.
- Check the contraindications.
- Evaluate the safety of therapy in the treatment of children.
- See the compatibility of drugs with alcohol (enter it as a drug).
- Point the doctor to the found interaction - you may need to adjust the therapy.
- The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
- The article is written: artificial intelligence Kiberis
- Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
- Total analyzed: 169,972,605 possible combinations of drugs and their components were found 412,508 interacting combinations.
- Medicine section: Standard evidence-based medicine
- The date of the last update of the interaction database: 2024-04-11
Category - medicine