Compatibility «Nise» and «Ekvator»
Between «Nise» and «Ekvator» found 3 dangerous and 5 negative interactions, joint admission is not recommended without consulting a doctor.
Interaction tableCompare |
Ekvator |
✘Nise [Nimesulide] Analogs | |
✘Ekvator [Amlodipine and more 1Lisinopril] Analogs |
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Interactions Nise with Ekvator
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Dangerous interactions
In patients with mild to moderate renal insufficiency (creatinine Cl 30-80 ml/min), with the combined administration of ACE inhibitors, angiotensin II receptor antagonists or substances that suppress the COX system (NSAIDs, antiplatelet agents), further deterioration of renal function and the occurrence of acute renal failure, which, as a rule, is reversible. In the elderly, patients with reduced BCC (in pm receiving diuretic therapy) or impaired renal function, the co-administration of NSAIDs, including selective COX-2 inhibitors, with ACE inhibitors, including lisinopril, may lead to deterioration of renal function, including possible acute renal failure. In some patients with impaired renal function (for example, in elderly patients or patients with dehydration) receiving NSAID therapy (in pm with selective COX-2 inhibitors), the simultaneous use of ACE inhibitors or ARA II may cause further deterioration of renal function, including the development of acute renal failure, and hyperkalemia. -
Negative interactions
ACE inhibitors and angiotensin II receptor antagonists. NSAIDs can reduce the effect of antihypertensive drugs. These interactions should be considered in patients taking nimesulide in combination with ACE inhibitors or angiotensin II receptor antagonists. In the case of prolonged use of nimesulide in the form of a gel in maximum doses, interactions with digoxin, phenytoin, lithium preparations, diuretics, cyclosporine, methotrexate, other NSAIDs, hypotensive and antidiabetic drugs cannot be excluded. NSAIDs (in pm, selective COX-2 inhibitors) and acetylsalicylic acid in doses > 3 g / day reduce the antihypertensive effect of lisinopril. -
Positive interactions
NSAIDs, including selective COX-2 inhibitors and high doses of acetylsalicylic acid (>3 g /day). -
Unclear interactions
NSAIDs (including selective COX-2 inhibitors). NSAIDs, including selective COX-2 inhibitors.
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Dangerous interactions
Decoding the colors of interactions and contraindications
Dangerous | — | a pronounced negative interaction or contraindication. |
Negative | — | negative interaction or side effect that may reduce effectiveness. |
Positive | — | the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug. |
No | — | the drugs do NOT interact, which is separately indicated in the instructions. |
Unclear | — | the system failed to pre-assess the danger. |
Video instruction
Additional information
- Kiberis checks interactions and evaluates drug compatibility online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
- Why do I need to
- Avoid dangerous prescriptions for your patients.
- Check the contraindications.
- Evaluate the safety of therapy in the treatment of children.
- See the compatibility of drugs with alcohol (enter it as a drug).
- Point the doctor to the found interaction - you may need to adjust the therapy.
- The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
- The article is written: artificial intelligence Kiberis
- Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
- Total analyzed: 169,974,420 possible combinations of drugs and their components were found 412,510 interacting combinations.
- Medicine section: Standard evidence-based medicine
- The date of the last update of the interaction database: 2024-05-02
Category - medicine