Hyoscinum bromhydricum

 An alkaloid from Hyoscyamus niger. Formula uncertain, с15H17NO Kletzinsky; с20H32N2O Wadgymar Preparation: Provings made with aqueous solutions of the sulphate of H.

 Dull, heavy and sleepy, and very giddy (after thirty minutes). Mind quite clear when engaged in conversation, but when left undisturbed, he relapsed into a dreamy condition, with the eyes wide open; twice he reached out a hand to an object on the table, and began to look about the floor, and when I asked him ‘ what for. He said, oh, I thought something had dropped off the table, the walls appear to move a little (after three quarters of an hour ); left alone he remained quiet, but inclined to be meddlesome when his attention was no engaged in conversation, grasping at objects on the table, or in the wastebasket on the floor, and attempting to remove them before the hand reached them, evidently misjudging the distance (after one hour); left alone, he lapsed into a state of forgetfulness and dreamy meddlesome delirium picking at objects, and, having reached them after several unsuccessful efforts, fumbling them about until he dropped them, and then, in the attempt to pick them up, losing his balance, and, but for constant attention, falling over; when aroused he rubbed his hand, gaped, and answered my question readily; a remark which I made at this time excited a irritability which he was unable to restrain, and every now and then the suppressed chuckle burst out into a hearty laugh (after two hours).

 Vertigo. Giddiness (after three quarters of an hour). Giddiness (after ten minutes); he staggered a little on rising form the chair (after forty minutes); Giddiness (after five minutes); on attempting to rise from a chair he began to reel (after twenty minutes); giddiness across the forehead (after forty five minutes); diminished (after two hours); he could walk without assistance, but still reeled a little (after three hours and a quarter); Much giddiness (after fifteen minutes) (after one hour) Excessive giddiness and staggered much in walking (after twenty minutes), legs felt weak and he was too giddy to walk without assistance (after one hour); too giddy to walk without laying hold of the furniture or supporting himself by the wall (after one hour and a half) rapidly passing off, Excessive giddiness and a weight across the forehead, continuing about an hour (after ten to twenty minutes), Reeled much in walking (after twelve minutes). (10) Tottering and giddiness, so that she had to make two or three efforts before she could raise herself from the chair, and then began to reel, and could not walk safely without support. Forehead. Great Weight across the forehead.
 Eye.
 Eyes suffused (after fifty minutes); natural (after two hours and a quarter). Membranes of the eyes sometimes slightly injected, continuing about an hour (after ten to twenty minutes), Sclerotic and conjunctiva a little injected (after one hour) quite gone (after two hour). сonjunctiva. сonjunctivae little injected after (thirty minutes); natural (after three hours). вall. Eyeball restless (after fifty minutes) eyeballs unsteady (after two hours) continuing an hour and a quarter. Pupil. The pupils slowly dilate during the latter part of the action of the medicine, and at its close attain their maximum degree of dilation. Pupils dilating (after twenty minutes); 1/5″ (after forty five minutes); a little over 1/5″ (after one hour). Pupils between 1/5″ and 1/4 (after two hours); nearly 1/4 at the light (after three hours and three quarters). Pupils 1/6 (before the proving; the dilatation was such that it half). Pupils at the light 1/8″ (before the proving); 1/5″ (after three hours and a half). Pupils 1/9 (before the proving);dilated to 1/8 (after two hour); Pupils 1/9 (before the proving); dilated to 1/8 (after one hour); 1/7″ (before the proving); dilated to 1/8 (after one hour); 1/7″ after one hour and a half); 1/6″ (after to hours). Pupils 1/10″ (before proving); 1/8″, sidewise 1/6″ (after three quarter of an hour). Pupils 1/100, sideways 1/7 (before the proving); dilated to 1/8″; sideways 1/6″ (after three quarters of an and, and two hours and a quarter). Pupils 1/10, sideways 1/7 (before the proving); 1/8″, sideways 1/7 (after one hour); 1/7″, sideways 1/5 (after two hours). Pupils 1/10, sideways 1/7 (before the proving); slightly dilated (after forty minutes); at light 1/7″, sideways 1/5″ (after two hours and a quarter). Pupils 1/10, sideways 1/7 (before the proving); 1/8″ (after thirty minutes); 1/7″, sideways 1/5 (after one hour and quarter); 1/6″, sideways 1/4 nearly (after two hours and a quarter). Vision. On endeavoring to read the paper at the usual distance, he was unable to decipher even the head lines; there was a thick haze before the eyes, he could not distinguish his finger nails and the letters appeared to run together to form and at the same time inclined the head backwards, making a distance of thirty six inches, he was able to read the smallest type of the Times news paper fluently, he recognized a lightning conductor, a rod of the thickness of the little finger, as a film projecting from the side of the chimney pot; by means of a double convex lens or a pinhole in a card he was able to read any type at a distance of three inches from the eye (after two hours and a half).
 Face.
 Looked very heavy, had slept, and a great somnolency continued (after fifty minutes); somnolency passing off (after two hours and a quarter), Some flushing of the face. Face a little flushed (after twenty minutes); Face, chiefly the cheeks, hot and flushed (after one hour) disappeared (after two hours). Face hot and flushed (after thirty minutes) Face hot and flushed (after fifty minutes); natural two hours and a quarter), сheeks occasionally a little flushed, continuing an hour (after ten to twenty minutes).

 Tongue. Anterior part and margins of the tongue quite wet with an acid secretion (after three hours). Tongue dry and brown remaining so for an hour and a half (after thirty minutes) Tongue dry and brown at the center (after two hours), Tongue dry and brown down the center, the rest of the mouth very clammy (after one hour) Tongue and mouth generally dry; Hard plate generally dry hard plate generally (after twenty minutes (Tongue more or less completely dry, rough, and brown the hard and soft palates dry or less completely dry, rough, and brown hard and soft plates dry and glazed (after ten to twenty minutes); after continuing about an hour, the tongue and hard and soft palates become covered over with a sticky, acid, offensive secretion, agreeing in all respects with that which follows the action of the вelladonna Tongue, excepting the margin, quite dry and brought (after forty five minutes). Articulation indistinct for the great dryness of the tongue and throat (after forty five minutes) Tip of the tongue quite dry (after thirty minutes) General Mouth. Dryness of the mouth and throat after effects. Mouth quite dry, excepting the gums (after one hour) Mouth and throat very dry and parched (after one hour and a half ) and remained so, slight dryness of the mouth (after two hour and a quarters) The mouth was parched. вoth palates dry and glazed (after twelve minutes) both plates dry and glazed, remaining so for an hour and a half (after thirty minutes). вoth plates dry and glazed (after two hours); a portion of the hard palates dry (after two hours and a half); soon passed off, вoth plates completely dry and glazed (after forty five minutes) Mouth clammy (after one hour) Mouth moist (after fifty minutes, and one hour and a quarter, and three hours). (60) Mouth moist and clammy and exhaling an offensive odor (after two hours), Mouth quite moist (after two hours). Mouth suddenly and completely moistened (between forty fourth and forty sixth minutes).
 Throat.
 Throat dry (after one hour): Very dry (after two hours) Although the mouth was moist, the throat was very dry (after one hour and a quarter).

 Urine, before taking, 2 ounces, acid, pale, Sp. gr. 1016; 1000 grains contained chlorine 4. 56 grains, urea 14. 80 grains phosphates and sulphates 7. 01 grains, uric acid nearly colorless, 9 ounces, sp. gr. 1008; 1000 grains con sulphates. 3. 75 grains, uric acid a trace;three hours after taking, an urgent call to pass water, dysuria and discharge contained Hyoscyamus ). Urine before taking, acid, pale sherry colored, sp. gr. 1015, two hours and a quarter after 1/48 grain, feebly acid, whey colored, sp. gr. 1010. Urine, before taking, acid, sp. gr. 1016, much uric acid; two hours after 1/30 grain, 15 1/2 ounces, alkaline sp. gr. 1008, much less uric acid. Urine before taking acid sp. gr. 1016. Much uric acid two hours and a quarter after 1/20 grain, neutral, sp. gr. 1008 a trace of uric acid, Urine, before taking, faintly acid, sp. gr. 1010; Two hours after 1/12 grain very alkaline, sp. gr. 1005, Urine, before taking acid, sp. gr. 1015, bright on boiling; 1000 grains contained chlorine 2. 95 grains, urea 12. 32 grains, sulphates and phosphates 4. 16 grains; two hours and a quarter after 1/8 grain alkaline, sp. gr. 1008, opalescent on boiling chlorine 1. 55 grains, urea 5. 33 grains, sulphates and phosphates 3. 24 grains; three hours after 1/8 grain, still more alkaline, otherwise about the same. Urine at time of injection, acid sp. gr. 1034; after twenty two minutes same, but a few drops dilated the pupil from 1/8 to 1/6, and maintained it so for ten hours. Urine before taking high colored acid; three hours and a half after, glucose green, sp. gr. 1007, quantity 15. 1/2 ounces (chloroform extracted a brown varnish smelling strongly of the original Hyoscyamus 2 drops of its solution in 10 drops of water dilated pupil). Urine half an hour after Hyoscyamus, acid, sp. gr. 1017; 1000 grains contained chlorine 3. 00 grains, urea 16. 66 grains, sulphates and phosphates 8. 60 grains; after two hours and half, acid sp. gr. 1023; 1000 grains contained chlorine 5. 49 grains, urea 21. 66 grains, sulphates and phosphates 8. 80 grains (both specimens normal in uric acid). Urine, before taking, acid sp. gr. 1010, bright on boiling; after two hours and a half, alkaline, sp. gr. 1025; much phosphatic opalescences on boiling, and deposit of triple phosphates on standing.

 Dry tracheal cough, during the last hour (after one hour and a quarter).

 After doses (1/16 to 1/12 of a grain) sufficient to produce complete dryness of the tongue and the hard and soft palates, the pulse will generally experience an acceleration of 10 or 20 beats, and be increased slightly in force and volume; this change in the pulse will be observed in from ten to twenty minutes after the subcutaneous injection of Hyoscyamine; the acceleration does not usually continue for longer than twenty or thirty minutes, and rarely lasts for an hour; then the pulse slowly declines, and gains a little in force and volume; it usually decreases about 5 beats for every interval of twenty or thirty minutes, until at the end of an hour and a half or two hours it attains its minimum rate; after a small dose (1/40 of a grain) the pulse will usually fall without any previous acceleration. Pulse 76 (before the proving) accelerated 26 beats of undiminished volume and power (after thirty minutes); accelerated 24 beats (after forty minutes); accelerated 12 beats (after minutes); fallen to 9 beats below the initial rate, regular, and of undiminished power and volume (after one hour and a quarter); decreased 18 beats, regular, software, of good volume (after two hours and quarter); decreased 21 beats, being now 53, regular, and of natural volume power (after three hours). Pulse 78 (before proving); rose 18 beats during the first twenty minutes, and then during the next two hours gradually fell to 20 beats below the initial rate; during the first half hour the force and volume were slightly increased; afterwards the pulse assumed its natural character. Pulse 74 (before the proving); increased 18 beats, regular (after twenty minutes); accelerated 8 beats (after one hour); 5 beats (after one hour and a half); 72, reduced 2 beats, of the same volume and power as before the injection (after two hours); still 72, regular, and of good volume (after two hours and a half). Pulse 76 (before proving; in creased 15 beats, regular, a little increased in volume (after twenty minutes); increased 4 beats (after one hour); 20 beats below the initial rate, of natural volume and power (after two hours). Pulse 74 (before the proving); accelerated 15 beats (after twenty three minutes); accelerated 10 beats, regular (after three quarters of an hour); 74, of natural volume and power (after one hour); 72 (after two hours). Pulse increased 12 natural volume force (after forty five minutes); pulse fallen 1 beat, full and regular (after one hour); decreased 6 beats, but still remained of good volume and force (after two hours) pulse 60, very regular, and of natural force and volume; it had continued so from the second hour (after three hours and three quarters). Pulse 88, after sitting an hour ( in much pain), (before the proving) decreased 6 beats, once or twice a minute, a beat came very slowly, otherwise quite regular (after fifteen minutes) further decreased 2 beats, quite regular, slightly increased in volume and power (after thirty minutes ). fell 7 beats and attained the minimum depression of 19 beats (between forty fourth minute and forty sixth minute) pulse 72 having increased 3 beats it was regular, and of slightly increased volume and power (after two hours and after, when it attained the minimum, numbering 48; during the next hour it rose to 50. pulse 76 (before the proving de creased 18 beats (after twenty minutes: (21 beats (after three quarters of an hour); 22 beats (after one hour); 25 beats now numbering 51 (after one hour and three quarters) 26 beats (after two hours and a quarter); at first the force and volume of the pulse were slightly increased, but afterwards it continued unchanged and regular throughout. Increased, but afterwards it continued unchanged and regular throughout.

 Limbs were fidgety, and occasionally affected with slight twitching (after two hours). Slight jerking of the limbs.
 Inferior Extremities.
 The legs were very weak and he could not walk without assistance (after twenty minutes). Legs felt too weak to walk (after one hour), He could not rise from his chair, or walk without assistance and as he sat, the extensors of the legs were slightly twitched now and then, so as to advanced the foot with a little jerk (after forty five minutes), Quite unable to walk (after two hours).

 The muscular system generally was flaccid, he did not sit erect in the chair, and a foot was occasionally advanced with a little jerk, and once or twice the hand was suddenly pronated and supinated with a jerk (after one hour). The power of maintaining the erect posture will be lost, and at best the patient reels like a drunken man. Somewhat restless for an hour and a quarter, and if I left his side for a minute he would attempt to get up, reel for a few paces, and then fall together like a drunken man, upon the carpet (after two hours). Felt heavy (after twenty minutes).

 Inclined to yawn (after one hour and three quarters). Frequently yawned and sighed (after one hour and a quarter). Gapish and tired (after three hours and a quarter) Slight inclination to sleep (after three hours and a quarter). Somnolency continuing about an hour (after ten to twenty minutes). Much somnolency, and had slept the last ten minutes (after one hour); had slept during the last hour, and still experienced somnolency (after two hours), Much somnolency (after fifteen minutes); continued very sleepy (after thirty minutes); she continued to sleep for an hour and awaking with a start, Great Somnolency for three hours. Great Somnolency (after twenty minutes); сontinuing (after one hour and a half) nearly passed off (after two hours). Greater somnolency and giddiness than after grain of acetate of morphia (used subcutaneously); the effects came on within the eyelids raised for a few seconds. Either wakeful, quiet, and he slept two hours soundly and continuously. Such excessive somnolency that the patient cannot keep the eyelids raised for a few seconds. Either wakeful, quiet, and unusually pleasing delirium, with illusions of the sight, or such excessive somnolency that the patient cannot keep the eyelids raised for a few seconds, but when aroused, lapses again in to a dreamy sleep, broken by occasional mutterings and slight jerking of the limbs.

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