Compatibility «Methylprednisolone» and «Dexamethasone»

• Interactions Methylprednisolone with Dexamethasone

  • Negative interactions
    • ⓘ Many drugs are CYP3A4 substrates, some of them alter the metabolism of GCS by induction or inhibition of CYP3A4.
    • ⓘ In the presence of another CYP3A4 substrate, a change in the hepatic clearance of methylprednisolone may require appropriate dose adjustment of GCS.
    • ⓘ Drugs that inhibit the activity of CYP3A4, such as ketoconazole, erythromycin, clarithromycin, diltiazem and cyclosporine (see table below), usually reduce hepatic clearance and increase plasma concentrations of CYP3A substrates such as methylprednisolone.
    • ⓘ In the presence of a CYP3A4 inhibitor, a lower dose of methylprednisolone may be required to avoid side effects.
    • ⓘ Drugs that induce CYP3A4 activity, such as phenobarbital, rifampicin, carbamazepine and phenytoin (see table below) usually increase hepatic clearance and lead to a decrease in plasma concentrations of drugs that are CYP3A4 substrates.
    • ⓘ Withdrawal of CYP3A4 inhibitors or inducers may return clinical changes to their original state and require careful dose adjustment of methylprednisolone.
    • ⓘ CYP3A4 inducers may enhance the metabolism of GCS, and an increase in the dose of GCS may be required.
    • ⓘ Drugs that induce CYP3A4 activity may enhance the metabolism of GCS, so an increase in the dose of GCS may be required.
    • ⓘ CYP3A4 inducers may enhance the metabolism of GCS, so an increase in the dose of GCS may be required.
    • ⓘ Simultaneous use of CYP3A4 inhibitors may lead to an increase in the concentration of GCS in blood plasma.
    • ⓘ CYP3A4 inhibitors can potentially lead to an increase in the concentration of GCS in blood plasma.
    • ⓘ Methylprednisolone and Dexamethasone belong to the same pharmaceutical group: Glucocorticosteroids.
  • Unclear interactions
    • ⓘ Methylprednisolone is a substrate of the cytochrome P450 system and is mainly metabolized by the CYP3A4 isoenzyme, which catalyzes the 6β-hydroxylation of steroids, the main phase of metabolism of endogenous and synthetic GCS.
    • ⓘ CYP3A4 substrates.
    • ⓘ CYP3A4 inhibitors.
    • ⓘ CYP3A4 inducers.
    • ⓘ The inductor of CYP3A4.
    • ⓘ Inducer and substrate of CYP3A4.
    • ⓘ Inhibitors and substrates of CYP3A4.
    • ⓘ Inhibitor and substrate of CYP3A4.
    • ⓘ Grapefruit juice is a CYP3A4 inhibitor.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 169,994,378 possible combinations of drugs and their components were found 412,530 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2024-12-19

Category - medicine