Compatibility «Amlodipine+Losartane» and «Hydrochlorothiazide»
Between «Amlodipine+Losartane» and «Hydrochlorothiazide» found 10 dangerous and 14 negative interactions, joint admission is not recommended without consulting a doctor.
Interaction tableCompare |
Hydrochlorothiazide |
✘Amlodipine+Losartane [Amlodipine and more 1Losartan] Analogs | |
✘Hydrochlorothiazide [Amlodipine and more 1Losartan] Analogs |
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Interactions Amlodipine+Losartane with Hydrochlorothiazide
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Dangerous interactions
- Calcium channel blockers(C08) + Drugs that cause hypokalemia; Glucocorticosteroids (C03A, A01AB04,J02AA01,H02,D07 => Increases the likelihood of ventricular tachycardia and ventricular fibrillation. (A dangerous combination, it is necessary to eliminate hypokalemia before use).
- In elderly patients with a decrease in the volume of intercellular fluid (including those receiving diuretics) or with impaired renal function, the combined use of NSAIDs, including selective COX-2 inhibitors, with ARA II (including losartan) may lead to deterioration of renal function, including the possible development of acute renal failure.
- The simultaneous use of ARA II or diuretics and NSAIDs may cause an increased risk of deterioration of renal function, in pm acute renal failure and increased potassium content in blood plasma, especially in patients with initial renal impairment.
- Metformin should be used with caution due to the risk of lactic acidosis caused by possible functional renal failure associated with the use of hydrochlorothiazide.
- Diuretics reduce the renal clearance of lithium and significantly increase the risk of its toxic effects.
- It is recommended to avoid simultaneous use of hydrochlorothiazide with lithium preparations.
- In the case of high doses of salicylates, hydrochlorothiazide may enhance their toxic effect on the central nervous system.
- Hypokalemia or hypomagnesemia caused by thiazide diuretics may contribute to the development of arrhythmias induced by cardiac glycosides.
- In the case of dehydration caused by the use of diuretics, the risk of acute renal failure increases, especially when taking high doses of iodine preparations.
- It should be used with caution with hypotensive drugs (their effect is potentiated, dose adjustment may be necessary), cardiac glycosides (hypokalemia and hypomagnesemia associated with the action of thiazide diuretics may increase the toxicity of digitalis), amiodarone (its use simultaneously with thiazide diuretics may lead to an increased risk of arrhythmias associated with hypokalemia), hypoglycemic oral medications (their effectiveness decreases, hyperglycemia may develop), corticosteroids, calcitonin (increase potassium excretion), NSAIDs (may weaken the diuretic and hypotensive effects of thiazides), non-depolarizing muscle relaxants (their effect may be enhanced), amantadine (clearance of amantadine may decrease with hydrochlorothiazide, which leads to an increase in plasma concentration of amantadine and possible toxicity), colestyramine (reduces absorption of hydrochlorothiazide), ethanol, barbiturates and narcotic analgesics, which enhance the effect of orthostatic hypotension.
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Negative interactions
- NSAIDs, in particular selective COX-2 inhibitors, can reduce the effect of diuretics and other antihypertensive agents.
- Other antihypertensive and antianginal drugs.
- Amlodipine can be safely used to treat hypertension together with thiazide diuretics, beta-blockers or ACE inhibitors.
- Other antihypertensive agents.
- In the presence of ion exchange resins, the absorption of hydrochlorothiazide is impaired.
- Taking a single dose of colestyramine or colestipol leads to the binding of hydrochlorothiazide and a decrease in its absorption from the gastrointestinal tract by 85 and 43%, respectively.
- It may be necessary to adjust the dose of anti-gouty drugs, since hydrochlorothiazide can increase the concentration of uric acid in blood plasma.
- Concomitant use with thiazides may increase the incidence of hypersensitivity reactions to allopurinol.
- It is possible to increase the bioavailability of thiazide diuretics by reducing gastrointestinal motility and the rate of gastric emptying.
- Isolated cases of hemolytic anemia have been described in patients receiving hydrochlorothiazide and methyldopa at the same time.
- Thiazide diuretics can increase the calcium content in blood plasma by reducing the excretion of calcium by the kidneys.
- Hydrochlorothiazide can cause the development of electrolyte deficiency, especially hypokalemia.
- Other antihypertensive drugs.
- It may be necessary to adjust the dose of simultaneously prescribed antihypertensive drugs.
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No interactions
- When taken simultaneously with thiazide diuretics, interaction with the following drugs may be observed.
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Positive interactions
- It is possible to enhance the antianginal and antihypertensive effects of BMCC when combined with thiazide and loop diuretics, ACE inhibitors, beta-blockers and nitrates.
- Thiazide diuretics can inhibit the excretion of cytotoxic drugs through the kidneys and enhance their myelosuppressive effect.
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Unclear interactions
- Amlodipine + Hydrochlorothiazide analgin and citramon are used together in Co-Exforge, Тритензин, Ko-Vamloset.
- Hydrochlorothiazide.
- Treatment with thiazide diuretics may affect glucose tolerance.
- Due to the effect on calcium metabolism, thiazides can distort the results of tests to assess the function of the parathyroid glands.
- Losartan + Hydrochlorothiazide analgin and citramon are used together in 20 preparations.
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Dangerous interactions
Decoding the colors of interactions and contraindications
Dangerous | — | a pronounced negative interaction or contraindication. |
Negative | — | negative interaction or side effect that may reduce effectiveness. |
Positive | — | the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug. |
No | — | the drugs do NOT interact, which is separately indicated in the instructions. |
Unclear | — | the system failed to pre-assess the danger. |
Video instruction
Additional information
- Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
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- The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
- The article is written: artificial intelligence Kiberis
- Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
- Total analyzed: 169,994,378 possible combinations of drugs and their components were found 412,530 interacting combinations.
- Medicine section: Standard evidence-based medicine
- The date of the last update of the interaction database: 2024-12-19
Category - medicine