Compatibility «Tenofovir» and «Dolutegravir»

• Interactions Tenofovir with Dolutegravir

  • Negative interactions
    • ⓘ Tenofovir and Dolutegravir belong to the same pharmaceutical group: HIV protease inhibitors.
    • ⓘ Tenofovir - no significant changes (increase in AUC by 12%, max'>C_max by 9% and C_τ by 19%).
  • No interactions
    • ⓘ In studies of interaction with drugs, dolutegravir did not have a clinically significant effect on the pharmacokinetics of tenofovir, ritonavir, methadone, efavirenz, lopinavir, atazanavir, darunavir, etravirine, fosamprenavir, rilpivirine, boceprevir, telaprevir, daclatasvir and oral contraceptives containing norgestimate and ethinyl estradiol.
    • ⓘ However, dolutegravir did not have a pronounced effect on the in vivo pharmacokinetics of tenofovir and paraaminohippurate OAT substrates and thus had a weak ability to induce drug interaction by inhibiting OAT transporters.
    • ⓘ Tenofovir, lopinavir/ritonavir, darunavir/ritonavir, rilpivirine, boceprevir, telaprevir, prednisone, rifabutin, daclatasvir and omeprazole had no effect or had minimal effect on the pharmacokinetics of dolutegravir, therefore, when used concomitantly with these drugs, dose adjustment of dolutegravir is not required.
  • Unclear interactions
    • ⓘ Tenofovir (nucleoside IOT).
    • ⓘ Tenofovir did not change the concentration of dolutegravir in blood plasma to a clinically significant extent.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 169,994,378 possible combinations of drugs and their components were found 412,530 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2024-12-19

Category - medicine