Compatibility «Acetylsalicylic acid» and «Perindopril+Amlodipine»

• Interactions Acetylsalicylic acid with Perindopril+Amlodipine

  • Dangerous interactions
    • ⓘ Concomitant use of ACE inhibitors and NSAIDs can lead to deterioration of renal function, including the development of acute renal failure, and an increase in serum potassium, especially in patients with impaired renal function.
    • ⓘ In the elderly, patients with insufficient BCC (in pm receiving diuretic therapy) or with impaired renal function, the combined use of NSAIDs, including selective COX-2 inhibitors, with ACE inhibitors, including perindopril, may lead to deterioration of renal function, including possible acute renal failure.
    • ⓘ It has been established that NSAIDs and ACE inhibitors have an additive effect on increasing the potassium content in blood serum, while impaired renal function is also possible.
  • Negative interactions
    • ⓘ Concomitant use of ACE inhibitors with NSAIDs (acetylsalicylic acid in an anti-inflammatory dose, COX-2 inhibitors and non-selective NSAIDs) may lead to a decrease in the antihypertensive effect of ACE inhibitors.
    • ⓘ Increases the toxicity of methotrexate, reducing its renal clearance, the effects of narcotic analgesics (codeine), oral antidiabetic drugs, heparin, indirect anticoagulants, thrombolytics and inhibitors of platelet aggregation, reduces the effect of uricosuric drugs (benzbromarone, sulfinpyrazone), hypotensive agents, diuretics (spironolactone, furosemide).
    • ⓘ Periodic monitoring of renal function is necessary in patients receiving perindopril and NSAIDs.
    • ⓘ The antihypertensive effect of ACE inhibitors, including perindopril, can be weakened by NSAIDs, including selective COX-2 inhibitors.
    • ⓘ Concomitant use of ACE inhibitors with NSAIDs (acetylsalicylic acid in an anti‑inflammatory dose, cyclooxygenase‑2 (COX-2) inhibitors and non-selective NSAIDs) may lead to a decrease in the antihypertensive effect of ACE inhibitors.
  • No interactions
    • ⓘ Perindopril can be used in conjunction with acetylsalicylic acid (as an antiplatelet agent), thrombolytic agents, beta-blockers and/or nitrates.
    • ⓘ Unlike other BMCC, no clinically significant interaction of amlodipine was found when combined with nonsteroidal anti-inflammatory drugs (NSAIDs), including indomethacin.
  • Positive interactions
    • ⓘ NSAIDs, including high doses of acetylsalicylic acid (>3 g / day).
    • ⓘ ACE inhibitors in combination with acetylsalicylic acid in higher doses.
    • ⓘ Nonsteroidal anti-inflammatory drugs (NSAIDs), including high doses of acetylsalicylic acid (more than 3 g / day).
  • Unclear interactions
    • ⓘ NSAIDs, including selective COX-2 inhibitors.
    • ⓘ Acetylsalicylic acid, thrombolytic agents, beta-blockers, nitrates.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 169,994,378 possible combinations of drugs and their components were found 412,530 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2024-12-19

Category - medicine