Compatibility «Amlodipine+Lisinopril» and «Acetylsalicylic acid»

• Interactions Amlodipine+Lisinopril with Acetylsalicylic acid

  • Dangerous interactions
    • ⓘ In the elderly, patients with reduced BCC (in pm receiving diuretic therapy) or impaired renal function, the co-administration of NSAIDs, including selective COX-2 inhibitors, with ACE inhibitors, including lisinopril, may lead to deterioration of renal function, including possible acute renal failure.
    • ⓘ In some patients with impaired renal function (for example, in elderly patients or patients with dehydration) receiving NSAID therapy (in pm with selective COX-2 inhibitors), the simultaneous use of ACE inhibitors or ARA II may cause further deterioration of renal function, including the development of acute renal failure, and hyperkalemia.
    • ⓘ Concomitant use of ACE inhibitors and NSAIDs should be carried out with caution (especially in elderly patients and in patients with impaired renal function).
    • ⓘ The use of lisinopril in combination with acetylsalicylic acid as an antiplatelet agent is not contraindicated.
  • Negative interactions
    • ⓘ Long-term use of NSAIDs, including high doses of acetylsalicylic acid more than 3 g /day, can reduce the antihypertensive effect of ACE inhibitors.
    • ⓘ The additive effect when taking NSAIDs and ACE inhibitors is manifested in an increase in serum potassium and can lead to deterioration of kidney function.
    • ⓘ As monotherapy, amlodipine was well combined with thiazide and loop diuretics, general anesthesia agents, beta-blockers, ACE inhibitors, long-acting nitrates, nitroglycerin, digoxin, warfarin, atorvastatin, sildenafil, antacid drugs (aluminum hydroxide, magnesium hydroxide), simeticone, cimetidine, NSAIDs, antibiotics and hypoglycemic agents for oral administration.
    • ⓘ Periodic monitoring of renal function in patients taking lisinopril and NSAIDs is recommended.
    • ⓘ NSAIDs can reduce the antihypertensive effect of ACE inhibitors, including lisinopril.
    • ⓘ NSAIDs (in pm, selective COX-2 inhibitors) and acetylsalicylic acid in doses > 3 g / day reduce the antihypertensive effect of lisinopril.
    • ⓘ Increases the toxicity of methotrexate, reducing its renal clearance, the effects of narcotic analgesics (codeine), oral antidiabetic drugs, heparin, indirect anticoagulants, thrombolytics and inhibitors of platelet aggregation, reduces the effect of uricosuric drugs (benzbromarone, sulfinpyrazone), hypotensive agents, diuretics (spironolactone, furosemide).
  • No interactions
    • ⓘ Unlike other BMCC, no clinically significant interaction of amlodipine was found when combined with nonsteroidal anti-inflammatory drugs (NSAIDs), including indomethacin.
  • Positive interactions
    • ⓘ NSAIDs, including selective COX-2 inhibitors and high doses of acetylsalicylic acid (>3 g /day).
    • ⓘ ACE inhibitors in combination with acetylsalicylic acid in higher doses.
  • Unclear interactions
    • ⓘ NSAIDs (including selective COX-2 inhibitors).
    • ⓘ NSAIDs, including selective COX-2 inhibitors.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 169,994,378 possible combinations of drugs and their components were found 412,530 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2024-12-19

Category - medicine