Compatibility «Hydrochlorothiazide+Lisinopril» and «Fluconazole»

• Interactions Hydrochlorothiazide+Lisinopril with Fluconazole

  • Negative interactions
    • ⓘ With repeated simultaneous use with hydrochlorothiazide, the maximum concentration of fluconazole in blood plasma increases by 40%.
    • ⓘ When taking fluconazole (100 mg) together with hydrochlorothiazide (50 mg) for 10 days, the level of fluconazole in the blood plasma of healthy volunteers (n = 13) increased by about 40%, renal clearance decreased by 30%.
    • ⓘ Repeated use of hydrochlorothiazide simultaneously with fluconazole leads to an increase in the concentration of fluconazole in blood plasma by 40%.
  • No interactions
    • ⓘ Dose adjustment of fluconazole is not required, but this interaction should be taken into account.
  • Unclear interactions
    • ⓘ · antifungal agents: azoles (voriconazole, itraconazole, ketoconazole, fluconazole);.
    • ⓘ Fluconazole.
    • ⓘ antifungal agents: azoles (voriconazole, itraconazole, ketoconazole, fluconazole);.
    • ⓘ Hydrochlorothiazide.
    • ⓘ The effect of this degree of severity does not require a change in the dosage regimen of fluconazole in patients receiving diuretics at the same time, however, the doctor should take this into account.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 170,037,924 possible combinations of drugs and their components were found 412,574 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2026-05-07

Category - medicine