Compatibility «Amitriptyline» and «Haloperidol»

• Interactions Amitriptyline with Haloperidol

  • Dangerous interactions
    • ⓘ Enhances the depressive effect on the central nervous system of neuroleptics, sedatives and hypnotics, anticonvulsants, analgesics, drugs for anesthesia, alcohol; shows synergism when interacting with other antidepressants.
    • ⓘ With the combined use of ethanol and drugs that depress the central nervous system (including antidepressants, barbiturates, benzadiazepines and general anesthetics), a significant increase in the depressive effect on the central nervous system, respiratory depression and hypotensive effect is possible.
    • ⓘ M-cholinergic blockers and antipsychotic drugs (neuroleptics) increase the risk of hyperpyrexia (especially in hot weather).
    • ⓘ Amitriptyline (N06AA09) + neuroleptics (N05) => Dangerous inhibition occurs.
    • ⓘ Inhibits the metabolism of tricyclic antidepressants (their plasma levels increase) and increases toxicity.
    • ⓘ Haloperidol potentiates the depressive effect on the central nervous system of antihypertensive drugs, narcotic analgesics, hypnotics, tricyclic antidepressants, general anesthesia, alcohol.
    • ⓘ Simultaneous use of haloperidol with drugs that prolong the QT interval, for example, antiarrhythmic drugs IA (in pm quinidine, disopyramide, procainamide) and III (in pm amiodarone, sotalol, dofetilide) of the class, some antimicrobials (sparfloxacin, moxifloxacin, erythromycin intravenously), tricyclic antidepressants (in pm amitriptyline), some tetracyclic antidepressants (in pm maprotilin), other neuroleptics (in pm phenothiazines, pimozide, sertindole), some antihistamines (in pm terfenadine), cisapride, bretilium tosylate, some antimalarial (in pm quinine, mefloquine) increases the risk of ventricular arrhythmias, including 'pirouette' type arrhythmias.
  • Negative interactions
    • ⓘ When used in combination with neuroleptics and / or anticholinergic drugs, it is possible to develop a febrile temperature reaction, paralytic intestinal obstruction.
    • ⓘ It enhances the effect of antihypertensive drugs, opioid analgesics, antidepressants, barbiturates, alcohol.
    • ⓘ When combined with anticonvulsants (including barbiturates and so on; inducers of microsomal oxidation), the doses of the latter should be increased, and haloperidol reduces the threshold of convulsive activity.
    • ⓘ Haloperidol slows down the metabolism of tricyclic antidepressants and monoamine oxidase (MAO) inhibitors, which increases their plasma concentration and toxicity.
    • ⓘ Long-term combined use of haloperidol with drugs that are inducers of liver enzymes (carbamazepine, rifampicin, phenobarbital, etc.) leads to a decrease in the concentration of haloperidol in blood plasma.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 169,994,378 possible combinations of drugs and their components were found 412,530 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2024-12-19

Category - medicine