Compatibility «Atorvastatin» and «Gestodene+Ethinylestradiol»

• Interactions Atorvastatin with Gestodene+Ethinylestradiol

  • Negative interactions
    • ⓘ After the combined use of atorvastatin with an oral contraceptive containing 2 mg of norethisterone and 35 mcg of ethinyl estradiol, plasma concentrations (AUC levels) of norethisterone (ratio AUC and max'>C_max atorvastatin 1.28 and 1.23, respectively, compared with the use of atorvastatin alone) and ethinyl estradiol (ratio AUC and the max'>C_max of atorvastatin 1.19 and 1.3, respectively, compared with the use of atorvastatin alone) increased.
    • ⓘ These changes should be taken into account when choosing an oral contraceptive.
    • ⓘ It is possible to interact with simultaneous use of atorvastatin with CYP3A4 inhibitors such as grapefruit juice, some macrolide antibiotics (e.g. erythromycin, clarithromycin), immunosuppressants (cyclosporine), azole antifungal drugs (e.g. itraconazole, ketoconazole), vector inhibitors, HIV and hepatitis C protease inhibitors, letermovir or the antidepressant nefazodone.
    • ⓘ Cyclosporine is an inhibitor of OATP1B1, OATP1B3, multidrug resistance protein (MDR1) and BCRP, as well as CYP3A4, therefore it increases the exposure of atorvastatin.
    • ⓘ Simultaneous use of atorvastatin and CYP3A4 inducers (e.g. efavirenz, rifampicin) may lead to a variable decrease in the concentration of atorvastatin in blood plasma.
    • ⓘ As a result of the dual mechanism of action of rifampicin (induction of CYP3A4 and inhibition of the OATP1B1 transporter), simultaneous co-administration of atorvastatin and rifampicin, etc. is recommended; delayed intake of atorvastatin after administration of rifampicin was associated with a significant decrease in the concentration of atorvastatin in blood plasma.
  • Unclear interactions
    • ⓘ Oral contraceptives and hormone replacement therapy.
    • ⓘ Atorvastatin is metabolized with the participation of the CYP3A4 isoenzyme.
    • ⓘ Clarithromycin and erythromycin are inhibitors of CYP3A4.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 169,994,378 possible combinations of drugs and their components were found 412,530 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2024-12-19

Category - medicine