Compatibility «Leflunomide» and «Levonorgestrel»

• Interactions Leflunomide with Levonorgestrel

  • Negative interactions
    • ⓘ An increase in side effects may occur when taking leflunomide and hepatotoxic compounds together.
    • ⓘ With hepatotoxic drugs and substances (including ethanol) or hematotoxic and immunosuppressive drugs.
    • ⓘ An increase in side effects may occur in the case of recent or concomitant use of hepatotoxic drugs and substances (including ethanol) or hematotoxic and immunosuppressive drugs, or when taking these drugs begins after treatment with leflunomide without a 'laundering' procedure (see the section 'Special instructions').
    • ⓘ In a study in which leflunomide was taken by healthy female volunteers, together with three-phase oral contraceptives containing 30 micrograms of ethinyl estradiol, no decrease in the contraceptive effect of the tablets was found, and the pharmacokinetics of A771726 fully fit into its usual range.
  • No interactions
    • ⓘ In drug interaction studies, the absence of a significant drug interaction between leflunomide and three-phase oral contraceptives has been demonstrated.
    • ⓘ However, an undesirable effect of this interaction on the effectiveness of oral contraceptives is not expected, it is recommended to take into account the type of contraceptive used.
  • Unclear interactions
    • ⓘ Hepatotoxic drugs.
    • ⓘ Effect on oral contraceptives (containing 0.03 mg of ethinyl estradiol and 0.15 mg of levonorgestrel).

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 169,994,378 possible combinations of drugs and their components were found 412,530 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2024-12-19

Category - medicine