Compatibility «Spironolactone» and «Potassium and magnesium orotate»

• Interactions Spironolactone with Potassium and magnesium orotate

  • Dangerous interactions
    • ⓘ Potassium iodide; Potassium citrate; Potassium bromide; Potassium chloride; Potassium aspartate; Orotic acid; Potassium and magnesium orotate(a12b) + Potassium-sparing diuretics(C03D, C03E) => Possible development of cardiac arrhythmias or cardiac arrest.
    • ⓘ Simultaneous administration of Spironolactone Medisorb with other potassium-sparing diuretics, ACE inhibitors, ARA II, aldosterone blockers, potassium preparations, as well as adherence to a potassium-rich diet, or the use of potassium-containing salt substitutes, can lead to the development of severe hyperkalemia.
  • Negative interactions
    • ⓘ Reduces the degree of magnesium deficiency and the risk of related complications when taking diuretics, aminoglycosides, cisplatin, cyclosporine, amphotericin, pentamidine, methotrexate, laxatives.
    • ⓘ Magnesium orotate should be used with caution if the patient is taking magnesium-containing medications such as antacids or laxatives, or potassium-sparing diuretics or medications containing calcium.
  • Unclear interactions
    • ⓘ Oral contraceptives, diuretics, muscle relaxants, glucocorticosteroids, and insulin reduce the effect of the drug.
    • ⓘ Oral contraceptives, diuretics, muscle relaxants, glucocorticoids, and insulin reduce the effectiveness of orotic acid.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 170,027,037 possible combinations of drugs and their components were found 412,563 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2026-01-01

Category - medicine