Compatibility «Spironolactone» and «Digoxin»

• Interactions Spironolactone with Digoxin

  • Dangerous interactions
    • ⓘ This can lead to an increase in serum digoxin levels and subsequent digitalis toxicity.
    • ⓘ Digoxin: spironolactone can increase the half-life of digoxin, which can lead to an increase in the concentration of digoxin in the blood serum and, as a result, increase its toxicity.
    • ⓘ glucocorticoids, saluretics and other drugs that promote potassium loss, calcium preparations - glycoside intoxication.
    • ⓘ Cardiac glycosides + Amphotericin B, diuretics-benzothiodiazines (dichlothiazide, cyclomethiazide, etc.), glucocorticoids and other drugs that cause hypokalemia, deoxycorticosterone acetate, corticotropin => Cardiac arrhythmia, increased toxic effects of cardiac glycosides.
  • Negative interactions
    • ⓘ Spironolactone has been shown to increase T_1/2 digoxin.
    • ⓘ When taking spironolactone, it may be necessary to reduce the dose of digoxin.
    • ⓘ The patient's condition should be carefully monitored to prevent digoxin overdose or insufficient digitalization.
    • ⓘ The effect of the drug on the results of laboratory studies: several cases of the effect of spironolactone or its metabolites on the digoxin concentration index determined by radioimmune analysis have been described in the literature.
    • ⓘ Diuretics, Diacarb, dichlotiazide, furosemide, ethacric acid + Amphotericin B, glucocorticoids, corticotropin, cardiac glycosides, laxatives and other agents that promote the excretion of potassium from the body => Cardiac dysfunction, muscle weakness and other manifestations of hypokalemia.
    • ⓘ Drugs that cause hypokalemia or intracellular potassium deficiency may cause hypersensitivity to digoxin; these include lithium salts, corticosteroids, carbenoxolone and some diuretics.
    • ⓘ When used concomitantly with diuretics such as loop or hydrochlorothiazide, serum electrolyte levels and renal function should be carefully monitored.
    • ⓘ Amiodarone, canagliflozin, daclatasvir, flibanserin, flecainide, prazosin, propafenone, quinidine, spironolactone, macrolide antibiotics, e.g. erythromycin and clarithromycin, tetracycline (and possibly other antibiotics), gentamicin, isavuconazole, itraconazole, ivacaftor, quinine, trimethoprim, alprazolam, indomethacin , propantelin, mirabegron, nefazodone, atorvastatin, cyclosporine, epoprostenol (transient effect), vasopressin receptor antagonists (tolvaptan and konivaptan), carvedilol, ritonavir/ treatment regimens containing ritonavir, telaprevir, dronedarone, ranolazine, simeprevir, telmisartan, lapatinib, ticagrelor, vandetanib, velpatasvir, venetoclax and vemurafenib.
  • Unclear interactions
    • ⓘ Digoxin.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 169,994,378 possible combinations of drugs and their components were found 412,530 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2024-12-19

Category - medicine