Compatibility «Spironolactone» and «Bisoprolol+Hydrochlorothiazide»

• Interactions Spironolactone with Bisoprolol+Hydrochlorothiazide

  • Dangerous interactions
    • ⓘ Lithium, as a rule, should not be taken with diuretics.
    • ⓘ Diuretics reduce the renal clearance of lithium and increase the risk of lithium toxicity.
  • Negative interactions
    • ⓘ In some patients, NSAIDs may reduce the diuretic, natriuretic and antihypertensive effects of loop, potassium-sparing and thiazide diuretics.
    • ⓘ If the previous intake of diuretics caused hyponatremia, it is necessary either to stop taking diuretics 3 days before the start of treatment with ACE inhibitors, or to start treatment with the latter in small doses, with a gradual increase in them.
    • ⓘ In the case of dehydration caused by taking a diuretic, the risk of acute liver failure increases, especially when taking high doses of iodine-containing contrast agents.
    • ⓘ Antihypertensive drugs: spironolactone potentiates the effect of antihypertensive drugs, the dose of which, when taken simultaneously with spironolactone, may need to be reduced and adjusted further if necessary.
    • ⓘ Nonsteroidal anti-inflammatory drugs (NSAIDs): In some patients, NSAIDs may reduce the diuretic, natriuretic and antihypertensive effects of loop, potassium-sparing and thiazide diuretics.
  • Unclear interactions
    • ⓘ Therefore, when using a combination of bisoprolol + hydrochlorothiazide and NSAIDs at the same time, the patient's condition should be closely monitored to determine whether the desired effect of the diuretic has been achieved.
    • ⓘ Potassium-sparing diuretics.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 169,994,378 possible combinations of drugs and their components were found 412,530 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2024-12-19

Category - medicine