Compatibility «Telmisartan» and «Captopril»

• Interactions Telmisartan with Captopril

  • Dangerous interactions
    • ⓘ With the simultaneous use of lithium preparations and ACE inhibitors or ARA II, including telmisartan, there was a reversible increase in the concentration of lithium in blood plasma, accompanied by toxic effects.
    • ⓘ Clinical studies have shown that double blockade of the renin-angiotensin-aldosterone system (RAAS) due to the combined use of ACE inhibitors, angiotensin II receptor blockers or aliskiren is associated with a higher frequency of adverse reactions such as hypotension, hyperkalemia and decreased renal function (including acute renal failure) compared with the use of a single agent acting on RAAS (see sections 'Contraindications', 'Special instructions' and 'Pharmacodynamics').
    • ⓘ Double blockade of the RAAS with the combined use of ARA II, ACE inhibitors or aliskiren is associated with an increased risk of hypotension, hyperkalemia and changes in renal function (including acute renal failure) compared to monotherapy.
    • ⓘ Double blockade of the RAAS with the use of ARA II, ACE inhibitors or aliskiren (renin inhibitor) is associated with an increased risk of hypotension, syncope, hyperkalemia and impaired renal function (including acute renal failure).
    • ⓘ ACE inhibitors (C09A) + angiotensin ii receptor antagonists => Are associated with an increased risk of arterial hypotension, syncope, hyperkalemia and impaired renal function (in pm acute renal failure) compared with monotherapy.
  • Negative interactions
    • ⓘ The risk may increase when combined with other medications that can also provoke hyperkalemia (salt substitutes containing potassium, potassium‑sparing diuretics, ACE inhibitors, angiotensin II receptor antagonists, nonsteroidal anti‑inflammatory drugs (NSAIDs, including selective COX-2 inhibitors), heparin, immunosuppressants (cyclosporine or tacrolimus) and co-trimoxazole (trimethoprim + sulfamethoxazole).
    • ⓘ Concomitant use with ACE inhibitors or NSAIDs, including selective COX‑2 inhibitors, is accompanied by a lower risk of hyperkalemia, provided careful observance of precautions.
    • ⓘ Other antihypertensive agents.
    • ⓘ The effect of telmisartan on lowering blood pressure can be enhanced by simultaneous administration of other antihypertensive medications.
    • ⓘ Based on their pharmacological properties, it can be expected that the following drugs can enhance the antihypertensive effect of all antihypertensive agents, including telmisartan: baclofen, amifostin.
    • ⓘ The effect of captopril is enhanced by the use of antihypertensive drugs that cause the release of renin.
    • ⓘ Concomitant use of ACE inhibitors with angiotensin II receptor antagonists.
    • ⓘ (ARA II) is contraindicated in patients with diabetic nephropathy and is not recommended in other patients.
    • ⓘ Simultaneous use of captopril with potassium-sparing diuretics (such as spironolactone, eplerenone, triamterene, amiloride), potassium preparations, potassium-containing salt substitutes and other drugs capable of increasing the potassium content in blood serum (including angiotensin II receptor antagonists, heparin, tacrolimus, cyclosporine; drugs containing cotrimoxazole [trimethoprim + sulfamethoxazole]) may lead to a significant increase in the potassium content in blood plasma.
    • ⓘ Other antihypertensive drugs.
    • ⓘ NSAIDs, including selective cyclooxygenase‑2 (COX‑2) inhibitors and acetylsalicylic acid in doses of 3 g/day and above, can reduce the antihypertensive effect of diuretics and other antihypertensive agents.
  • No interactions
    • ⓘ Captopril can be safely used in combination with other antihypertensive drugs (such as beta‑blockers or long-acting 'slow' calcium channel blockers).

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 169,994,378 possible combinations of drugs and their components were found 412,530 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2024-12-19

Category - medicine