Compatibility «Warfarin» and «Fluconazole»

• Interactions Warfarin with Fluconazole

  • Dangerous interactions
    • ⓘ Exogenous factors: potentially possible interaction of warfarin and drugs of the following classes and groups: 5-lipoxygenase inhibitors, adrenostimulants, drugs of central action to reduce alcohol abuse, analgesics, inhaled anesthetics, antiandrogens, antiarrhythmic drugs, antibiotics¹ (oral aminoglycosides, parenteral cephalosporins, macrolides, IV high-dose penicillins, macrolides, tetracyclines), quinolone antibacterial drugs, long-acting sulfonamides, anticoagulants, anticonvulsants¹, antidepressants¹, intravaginal and systemic antifungal drugs¹, antimalarial drugs, antitumor drugs¹, antiparasitic and antimicrobial drugs¹, platelet aggregation inhibitors, antiteroid drugs¹, beta-blockers, cholelitolytic drugs, antidiabetic drugs, oral diuretics¹, drugs that regulate the acidity of gastric juice and anti-ulcer drugs¹, prokinetics, drugs for the treatment of gout, hemorheological drugs, drugs for the treatment of ulcerative colitis, hepatotoxic drugs, hyperglycemic drugs, emergency medications for hypertension, hypnotic drugs¹, leukotriene receptor antagonists, lipid-lowering drugs (fibrates, HMG-CoA reductase inhibitors, bile acid sequestrants)¹, MAO inhibitors, long-acting narcotic drugs, drugs of natural origin, NSAIDs (non-selective COX-2 inhibitors), psychostimulants, pyrazolones, salicylates, SSRIs, adrenocorticosteroids, anabolic steroids (derivatives of 17-alkyltestosterone), thrombolytics, thyroid agents, anti-tuberculosis drugs, uricosuric drugs, vaccines, vitamins¹.
    • ⓘ Exogenous factors: potentially possible interaction of warfarin and drugs of the following classes and groups: steroid inhibitors of the adrenal cortex, antacids, sedatives, antiarrhythmic drugs¹, antibiotics¹, anticonvulsants¹, antidepressants¹, antifungal drugs of systemic action¹, antihistamines, antitumor drugs¹, neuroleptics, antireoid agents¹, barbiturates, diuretics¹, enteral dietary supplements , enzyme inhibitors, drugs for the regulation of gastric acidity and treatment of peptic ulcer¹, hypnotic drugs¹, immunosuppressants, lipid-lowering drugs (bile acid sequestrants, HMG-CoA reductase inhibitors)¹, drugs of natural origin, oral contraceptives, selective estrogen receptor modulators, adrenocorticosteroids, anti-tuberculosis drugs¹, vitamins¹.
  • Negative interactions
    • ⓘ There have been reports of changes in INR in patients taking warfarin and antibiotics or antifungal drugs, but clinical pharmacokinetic studies have not shown a consistent effect of these drugs on the concentration of warfarin in blood plasma.
    • ⓘ Simultaneous use of these drugs and warfarin should be avoided or INR should be carefully monitored when starting or stopping any antibiotic or antifungal drug in patients taking warfarin.
    • ⓘ With the combined use of fluconazole and coumarin-type anticoagulants, PV may be prolonged, and therefore bleeding may develop (hematomas, nosebleeds and gastrointestinal tract, hematuria and melena); careful monitoring of PV is recommended, a change in the dose of warfarin may be required.
    • ⓘ Like other antifungal agents (azole derivatives), fluconazole, when used concomitantly with warfarin, increases prothrombin time (by 12%), which may lead to the development of bleeding (hematomas, nosebleeds and gastrointestinal tract, hematuria, melena).
    • ⓘ The expediency of dose adjustment of these anticoagulants should also be evaluated.
  • Unclear interactions
    • ⓘ This includes drugs intended for short-term use (for example, antibiotics, antifungal drugs, GCS).
    • ⓘ Antibiotics and antifungal drugs.
    • ⓘ Anticoagulants.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
• Why do I need to
  • Avoid dangerous prescriptions for your patients.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 170,027,037 possible combinations of drugs and their components were found 412,563 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2026-01-01

Category - medicine