Compatibility «Warfarin» and «Amiodarone»

• Interactions Warfarin with Amiodarone

  • Dangerous interactions
    • ⓘ Exogenous factors: potentially possible interaction of warfarin and drugs of the following classes and groups: 5-lipoxygenase inhibitors, adrenostimulants, drugs of central action to reduce alcohol abuse, analgesics, inhaled anesthetics, antiandrogens, antiarrhythmic drugs, antibiotics¹ (oral aminoglycosides, parenteral cephalosporins, macrolides, IV high-dose penicillins, macrolides, tetracyclines), quinolone antibacterial drugs, long-acting sulfonamides, anticoagulants, anticonvulsants¹, antidepressants¹, intravaginal and systemic antifungal drugs¹, antimalarial drugs, antitumor drugs¹, antiparasitic and antimicrobial drugs¹, platelet aggregation inhibitors, antiteroid drugs¹, beta-blockers, cholelitolytic drugs, antidiabetic drugs, oral diuretics¹, drugs that regulate the acidity of gastric juice and anti-ulcer drugs¹, prokinetics, drugs for the treatment of gout, hemorheological drugs, drugs for the treatment of ulcerative colitis, hepatotoxic drugs, hyperglycemic drugs, emergency medications for hypertension, hypnotic drugs¹, leukotriene receptor antagonists, lipid-lowering drugs (fibrates, HMG-CoA reductase inhibitors, bile acid sequestrants)¹, MAO inhibitors, long-acting narcotic drugs, drugs of natural origin, NSAIDs (non-selective COX-2 inhibitors), psychostimulants, pyrazolones, salicylates, SSRIs, adrenocorticosteroids, anabolic steroids (derivatives of 17-alkyltestosterone), thrombolytics, thyroid agents, anti-tuberculosis drugs, uricosuric drugs, vaccines, vitamins¹.
    • ⓘ Exogenous factors: potentially possible interaction of warfarin and drugs of the following classes and groups: steroid inhibitors of the adrenal cortex, antacids, sedatives, antiarrhythmic drugs¹, antibiotics¹, anticonvulsants¹, antidepressants¹, antifungal drugs of systemic action¹, antihistamines, antitumor drugs¹, neuroleptics, antireoid agents¹, barbiturates, diuretics¹, enteral dietary supplements , enzyme inhibitors, drugs for the regulation of gastric acidity and treatment of peptic ulcer¹, hypnotic drugs¹, immunosuppressants, lipid-lowering drugs (bile acid sequestrants, HMG-CoA reductase inhibitors)¹, drugs of natural origin, oral contraceptives, selective estrogen receptor modulators, adrenocorticosteroids, anti-tuberculosis drugs¹, vitamins¹.
    • ⓘ When warfarin is combined with amiodarone, the effects of an indirect anticoagulant may increase, which increases the risk of bleeding.
  • Negative interactions
    • ⓘ Inhibitors of CYP2C9, CYP1A2 and/or CYP3A4 can potentially enhance the effect (increase INR) of warfarin by increasing its exposure.
    • ⓘ Inducers CYP2C9, CYP1A2 and/or CYP3A4 can potentially reduce the effect (decrease INR) of warfarin by reducing its exposure.
    • ⓘ Examples of drugs with the potential to interact with warfarin are: tissue plasminogen activator, allopurinol, aminosalicylic acid, amiodarone, amoxicillin, argatroban, acetylsalicylic acid, azithromycin, bezafibrate, benzbromarone, benzylpenicillin (IV), benziodarone, bivalirudin, influenza virus vaccine, valproate, vitamin E, voriconazole, gatifloxacin, gefitinib, gemfibrozil, glucagon, glucosamine, halothane, heparin, danazol, danshen (Chinese herb), desirudin, dextran, dextrothyroxine, diazoxide, diclofenac, dicumarol, diflunizal, disulfiram, doxycycline, zafirlukast, ibuprofen, ifosfamide, indomethacin, itraconazole, capecitabine, carboplatin, ketoprofen, ketorolac, clarithromycin, clofibrate, co-trimaxosol, colestyramine¹, lansoprazole, leflunomide, lepirudine, levamisole, levofloxacin, levothyroxine, liothyronine , lovastatin, medroxyprogesterone, mephenamic acid, megestrol, memantine, methandienone, methimazole¹, methyldopa, methylprednisolone, methylphenidate, methyl salicylate (topical ointment), metronidazole, miconazole (intravaginal, oral, systemic¹), moricizine¹, moxifloxacin, nalidixic acid, naproxen, neomycin, norfloxacin, noscapine, ofloxacin, olsalazine, omeprazole, orlistat, oxandrolone, oxaprosine, oxolamine, oxymetholone, paclitaxel, pantoprazole, paracetamol, paroxetine, pentoxifylline, piperacillin, piroxicam, prasugrel, pravastatin, prednisolone ¹, propafenone, propoxyphene, propranolol, propylthiouracil¹, rabeprazole, ranitidine¹, rofecoxib, roxithromycin, sertraline, simvastatin, stanozolol, streptokinase, sulfamethisole, sulfamethoxazole, sulfinpyrazone, sulfisoxazole, sulindac, tamoxifen, tegafur, telithromycin, tetracycline, thyroid, ticarcillin, thienylic acid, ticlopidine, tolbutamide, tolterodine, toremifene, tramadol, urokinase, phenylbutazone, phenytoin¹, fenoprofen, fenofibrate, fluvastatin, fluvoxamine, fluoxetine, fluconazole, flutamide, fluorouracil, henodiol, quinidine, quinine, chloramphenicol, chloral hydrate¹, chlorpropamide, cefaclor, cefamandole, cefazolin, cefixime, cefonicide, cefoperazone, cefotetan, cefotiam, cefoxitin, ceftriaxone, cefuroxime, celecoxib, cyclophosphamide¹, cimetidine, ciprofibrate, ciprofloxacin, cisapride, citalopram, econazole, erythromycin, escitalopram, esomeprazole, ethacric acid, ezetimibe, as well as other drugs that affect the constituent components of the blood, which can change hemostasis, nutrient deficiency, prolonged hot weather, unreliable results for determining PV.
    • ⓘ Drugs that are substrates of the CYP2C9 isoenzyme Amiodarone increases the concentration in the blood of drugs that are substrates of the CYP2C9 isoenzyme, such as warfarin or phenytoin by inhibiting the CYP2C9 isoenzyme.
    • ⓘ Prothrombin time should be monitored more often by determining the INR index (international normalized ratio) and dose adjustments of indirect anticoagulants should be carried out both during treatment with amiodarone and after discontinuation of its administration.
  • Positive interactions
    • ⓘ Enhances the effect of indirect anticoagulants, digitalis preparations.
  • Unclear interactions
    • ⓘ CYP450 isoenzymes involved in warfarin metabolism include CYP2C9, CYP2C19, CYP2C8, CYP2C18, CYP1A2 and CYP3A4.
    • ⓘ The more active S-enantiomer of warfarin (60% of the total anticoagulation response) is metabolized with the participation of CYP2C9, while the R-enantiomer is metabolized by CYP1A2 and CYP3A4.
    • ⓘ Warfarin.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 169,994,378 possible combinations of drugs and their components were found 412,530 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2024-12-19

Category - medicine