Compatibility «Warfarin» and «Rivaroxaban»

• Interactions Warfarin with Rivaroxaban

  • Dangerous interactions
    • ⓘ The simultaneous use of enoxaparin sodium, warfarin, acetylsalicylic acid, clopidogrel and the constant use of NSAIDs may increase the risk of bleeding.
  • Negative interactions
    • ⓘ Warfarin and Rivaroxaban belong to the same pharmaceutical group: Anticoagulants.
    • ⓘ In another study, single doses of warfarin (15 mg) and rivaroxaban (5 mg) resulted in an additive effect on the inhibition of factor Xa and PV.
    • ⓘ Starting from the 4th day after discontinuation of warfarin, all laboratory parameters (in pm, APTT, inhibition of factor Xa and EPT activity) reflect only the effect of the drug Xarelto (see 'Method of administration and doses').
  • No interactions
    • ⓘ Neither enoxaparin sodium nor warfarin affected the pharmacokinetics of rivaroxaban.
    • ⓘ If it is necessary to study the pharmacodynamic effects of Xarelto during the transition period, the necessary tests that are not affected by warfarin can be used to determine the activity of the anti-factor Xa, prothrombinase-induced clotting time and NepTest.
    • ⓘ If it is necessary to investigate the pharmacodynamic effects of warfarin during the transition period, you can use the MHO value at C_trouble rivaroxaban (24 hours after taking the first dose of rivaroxaban), etc.; at this point in time, rivaroxaban has virtually no effect on this indicator.
  • Positive interactions
    • ⓘ The transition of patients from warfarin (MHO = 2 to 3) to Xarelto (20 mg) or from Xarelto (20 mg) to warfarin (MHO = 2 to 3) increased PV/INR (Neoplastin) more than with a simple summation of effects (individual MHO values can reach 12), while the effect on APTT, the suppression of factor Xa activity and the effect on the endogenous potential of thrombin (EPT) was additive.
    • ⓘ Direct-acting anticoagulants (heparin) + Anticoagulants of indirect action => Mutual enhancement of action, hemorrhagic syndrome is possible.
  • Unclear interactions
    • ⓘ No PCBs have been reported between warfarin and the drug Xarelto.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 170,023,408 possible combinations of drugs and their components were found 412,559 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2025-11-20

Category - medicine