Compatibility «Nebivolol» and «Amlodipine+Perindopril»

• Interactions Nebivolol with Amlodipine+Perindopril

  • Dangerous interactions
    • ⓘ With the simultaneous use of nebivolol with dihydropyridine-type BMCC (for example, amlodipine, felodipine, lacidipine, nifedipine, nicardipine, nimodipine, nitrendipine), it is possible to increase the risk of arterial hypotension and decrease left ventricular contractility in patients with CHF.
    • ⓘ When used simultaneously with hypotensive agents of central action (for example, clonidine, guanfacine, moxonidine, methyldopa, rilmenidine), the course of CHF may worsen due to a decrease in central sympathetic tone (decreased heart rate and cardiac output, vasodilation).
  • Negative interactions
    • ⓘ Antihypertensive agents (e.g. beta-blockers) and vasodilators.
    • ⓘ Calcium channel blockers enhance the blockade of AV conduction, Class I antiarrhythmics and amiodarone prolong the time of atrial excitation.
    • ⓘ With the simultaneous use of beta‑blockers with blockers of 'slow' calcium channels (BMCC) (for example, verapamil, diltiazem), the negative effect on contractility and AV conduction increases.
    • ⓘ Amlodipine can be safely used to treat hypertension together with thiazide diuretics, beta-blockers or ACE inhibitors.
  • No interactions
    • ⓘ In patients with stable angina pectoris, amlodipine can be used in combination with other antianginal agents, for example, with prolonged or short-acting nitrates beta-blockers.
    • ⓘ Perindopril can be used in conjunction with acetylsalicylic acid (as an antiplatelet agent), thrombolytic agents, beta-blockers and/or nitrates.
  • Positive interactions
    • ⓘ It is possible to enhance the antianginal and antihypertensive effects of BMCC when combined with thiazide and loop diuretics, ACE inhibitors, beta-blockers and nitrates.
  • Unclear interactions
    • ⓘ Amlodipine + Nebivolol analgin and citramon are used together in Nebilong AM.
    • ⓘ Acetylsalicylic acid, thrombolytic agents, beta-blockers, nitrates.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 169,994,378 possible combinations of drugs and their components were found 412,530 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2024-12-19

Category - medicine