Compatibility «Irbesartan» and «Spironolactone»

• Interactions Irbesartan with Spironolactone

  • Dangerous interactions
    • ⓘ Previous treatment with high-dose diuretics can lead to dehydration of the body and increases the risk of arterial hypotension at the beginning of treatment with irbesartan.
    • ⓘ Increases the risk of hyperkalemia when used in combination with potassium-sparing diuretics and potassium preparations.
    • ⓘ Previous treatment with high-dose diuretics may lead to hypovolemia and an increased risk of excessive blood pressure reduction at the beginning of treatment with Aprovel.
    • ⓘ Simultaneous administration of Spironolactone Medisorb with other potassium-sparing diuretics, ACE inhibitors, ARA II, aldosterone blockers, potassium preparations, as well as adherence to a potassium-rich diet, or the use of potassium-containing salt substitutes, can lead to the development of severe hyperkalemia.
  • Negative interactions
    • ⓘ Diuretics and other antihypertensive agents.
    • ⓘ Based on the experience gained with the use of other drugs that affect the RAAS, with the simultaneous use of potassium preparations; salt substitutes containing potassium; potassium-sparing diuretics or others capable of increasing the potassium content in the blood of drugs (heparin), it is possible to increase the potassium content in the blood serum, which requires careful monitoring of blood plasma potassium levels in patients during treatment.
    • ⓘ Angiotensin II antagonists, aldosterone blockers, heparin, low molecular weight heparin and other drugs that cause hyperkalemia.
    • ⓘ Antihypertensive drugs: spironolactone potentiates the effect of antihypertensive drugs, the dose of which, when taken simultaneously with spironolactone, may need to be reduced and adjusted further if necessary.
  • Unclear interactions
    • ⓘ Potassium supplements and potassium-sparing diuretics.
    • ⓘ Potassium preparations and potassium-sparing diuretics, heparin.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 169,994,378 possible combinations of drugs and their components were found 412,530 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2024-12-19

Category - medicine