Compatibility «Carvedilol» and «Amiodarone»

• Interactions Carvedilol with Amiodarone

  • Dangerous interactions
    • ⓘ Caution should be used with antiarrhythmic drugs and BCG, especially with diltiazem and verapamil (incompatible with intravenous administration of calcium antagonists).
    • ⓘ Compared with patients receiving carvedilol in monotherapy, in patients with heart failure receiving carvedilol simultaneously with amiodarone, the concentration of R and S stereoisomers of carvedilol increased 2.2 times immediately before taking the next dose.
  • Negative interactions
    • ⓘ The effect of the S stereoisomer of carvedilol is manifested by desethylamiodarone, a metabolite of amiodarone, which is a potent inhibitor of the CYP2C9 isoenzyme.
    • ⓘ It is recommended to monitor beta‑adrenoblocking activity in patients receiving carvedilol simultaneously with amiodarone.
    • ⓘ As with other drugs with beta‑adrenoblocking properties, the use of carvedilol simultaneously with NBMCC such as verapamil or diltiazem, amiodarone or other antiarrhythmic drugs is recommended to be carried out under the supervision of an electrocardiogram (ECG) and blood pressure.
  • Unclear interactions
    • ⓘ Amiodaronum.
    • ⓘ In vitro studies with human liver microsomes have shown that amiodarone and desethylamiodarone inhibited the oxidation of the R and S stereoisomer of carvedilol.
    • ⓘ Non-dihydropyridine blockers of 'slow' calcium channels (NBMCC), amiodarone or other antiarrhythmic agents.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 169,994,378 possible combinations of drugs and their components were found 412,530 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2024-12-19

Category - medicine