Compatibility «Carvedilol» and «Digoxin»

• Interactions Carvedilol with Digoxin

  • Negative interactions
    • ⓘ When used in combination with cardiac glycosides, diuretics and/ or ACE inhibitors, AV conduction may slow down.
    • ⓘ Increases the content of digoxin in the blood serum.
    • ⓘ Thus, it is recommended to monitor the concentration of digoxin at the time of initiation of therapy, dose selection and discontinuation of carvedilol therapy (see the section 'Special instructions').
    • ⓘ Combination therapy of drugs with beta‑adrenoblocking properties and digoxin may lead to an additional slowdown in atrioventricular conduction.
    • ⓘ Amiodarone, canagliflozin, daclatasvir, flibanserin, flecainide, prazosin, propafenone, quinidine, spironolactone, macrolide antibiotics, e.g. erythromycin and clarithromycin, tetracycline (and possibly other antibiotics), gentamicin, isavuconazole, itraconazole, ivacaftor, quinine, trimethoprim, alprazolam, indomethacin , propantelin, mirabegron, nefazodone, atorvastatin, cyclosporine, epoprostenol (transient effect), vasopressin receptor antagonists (tolvaptan and konivaptan), carvedilol, ritonavir/ treatment regimens containing ritonavir, telaprevir, dronedarone, ranolazine, simeprevir, telmisartan, lapatinib, ticagrelor, vandetanib, velpatasvir, venetoclax and vemurafenib.
  • No interactions
    • ⓘ At the same time, carvedilol has no effect on the pharmacokinetics of intravenously administered digoxin.
  • Positive interactions
    • ⓘ In studies in healthy volunteers and patients with heart failure, there was a 20% increase in digoxin exposure.
  • Unclear interactions
    • ⓘ Digoxin.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 169,994,378 possible combinations of drugs and their components were found 412,530 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2024-12-19

Category - medicine