Compatibility «Simvastatin» and «Fenofibrate»

• Interactions Simvastatin with Fenofibrate

  • Dangerous interactions
    • ⓘ When taking fenofibrate simultaneously with HMG-CoA reductase inhibitors or other fibrates, the risk of rhabdomyolysis, myopathy and acute renal failure increases (combined use is not recommended).
    • ⓘ When taking fenofibrate simultaneously with HMG-CoA reductase inhibitors or other fibrates, the risk of serious toxic effects on muscle fibers increases.
  • Negative interactions
    • ⓘ The average AUC of simvastatin acid, the main active metabolite, decreased by 42% while taking fenofibrate (range of changes: from a decrease of 77% to an increase of 50%).
    • ⓘ Fenofibrate had no effect (0%) on the average value of max'>C_max simvastatin acid (range of changes: from a decrease of 67% to an increase of 92%).
    • ⓘ The average C_min of fenofibroic acid increased by 14% (range of changes: from a decrease of 7% to an increase of 48%) after the use of simvastatin, which indicates the absence of the effect of simvastatin at a dose of 40 mg on the concentration of fenofibroic acid in blood plasma.
  • Unclear interactions
    • ⓘ nicotinic acid in lipid-lowering doses (more than 1 g / day), fibrates,.
    • ⓘ HMG-CoA reductase inhibitors and other fibrates.
    • ⓘ Simvastatin.
    • ⓘ On day 10, simvastatin at a dose of 40 mg was added to fenofibrate.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 169,994,378 possible combinations of drugs and their components were found 412,530 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2024-12-19

Category - medicine