Compatibility «Bisoprolol» and «Verapamil»

• Interactions Bisoprolol with Verapamil

  • Dangerous interactions
    • ⓘ beta-blockers (C07) + Verapamil, reserpine, phenigidine => Increased existing heart failure, bradycardia, impaired conduction.
    • ⓘ Beta-blockers, class IA antiarrhythmics, cardiac glycosides, inhalation anesthetics, radiopaque substances potentiate (mutually) depressing effects on the automatism of the sinoatrial node, AV conduction and myocardial contractility.
    • ⓘ Simultaneous intravenous administration of verapamil and beta-blockers led to serious side effects (severe bradycardia), especially in patients with cardiomyopathy, heart failure or recent myocardial infarction.
    • ⓘ Verapamil (C08DA01) + Beta-blockers (C07) => The risk of angina pectoris, AU block, hypotension, and heart failure increases. During treatment with verapamil, p-adrenergic receptor blockers should not be administered intravenously. There is a pronounced negative chronotropic (up to cardiac arrest), inotropic (up to the development of acute left ventricular failure) and dromotropic (up to complete AV block) effect. The probability increases dramatically with initial cardiac dysfunction and with intravenous administration of drugs against the background of a course of beta-blockers. (A dangerous combination, although its use may be justified in the treatment of arrhythmias, severe forms of angina pectoris occurring against a background of pronounced tachycardia not associated with congestive heart failure. Monitoring of contractility, conduction, heart rate. Intravenous administration of beta-blockers against the background of treatment with verapamil or vice versa is contraindicated).
  • Negative interactions
    • ⓘ The probability of violations of automatism, conduction and contractility of the heart increases (mutually) against the background of amiodarone, diltiazem, verapamil, quinidine preparations, cardiac glycosides, reserpine, alpha-methyldopha.
    • ⓘ Blockers of 'slow' calcium channels (BMCC) such as verapamil and to a lesser extent diltiazem, when used simultaneously with bisoprolol, can lead to a decrease in myocardial contractility and impaired AV conduction.
    • ⓘ In particular, intravenous administration of verapamil to patients taking beta‑blockers can lead to severe arterial hypotension and AV blockage.
  • Unclear interactions
    • ⓘ Beta blockers.
    • ⓘ Beta-blockers should be prescribed a few hours before or a few hours after the use of verapamil.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 169,994,378 possible combinations of drugs and their components were found 412,530 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2024-12-19

Category - medicine