Compatibility «Clarithromycin» and «Rivaroxaban»
Between «Clarithromycin» and «Rivaroxaban» found 2 dangerous and 1 negative interaction, joint admission is not recommended without consulting a doctor.
Interaction tableCompare |
Rivaroxaban |
✘Clarithromycin Analogs | |
✘Rivaroxaban Analogs |
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Interactions Clarithromycin with Rivaroxaban
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Dangerous interactions
- Although clarithromycin is a combined P-gp inhibitor and a strong CYP3A inhibitor, pharmacokinetic data suggest that no precautions are required when used in combination with rivaroxaban, since it is unlikely that a change in exposure will affect the risk of bleeding.
- Powerful CYP3A4 inducers should be used with caution in patients with coronary heart disease, ZPA or after ACS receiving Xarelto 2.5 mg 2 times a day.
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Negative interactions
- Clarithromycin (500 mg 2 per day), which is considered a potent inhibitor of CYP3A4 and a moderate inhibitor of P-gp, led to an increase in the average equilibrium AUC and average max'>Cmax rivaroxaban by 1.5 and 1.4 times, respectively.
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Unclear interactions
- Rivaroxaban is a substrate of CYP3A4/5, CYP2J2 isoenzymes and P-gp and ABCG2 transporters.
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Dangerous interactions
Decoding the colors of interactions and contraindications
Dangerous | — | a pronounced negative interaction or contraindication. |
Negative | — | negative interaction or side effect that may reduce effectiveness. |
Positive | — | the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug. |
No | — | the drugs do NOT interact, which is separately indicated in the instructions. |
Unclear | — | the system failed to pre-assess the danger. |
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Additional information
- Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
- Why do I need to
- Avoid dangerous prescriptions for your patients.
- Check the contraindications.
- Evaluate the safety of therapy in the treatment of children.
- See the compatibility of drugs with alcohol (enter it as a drug).
- Point the doctor to the found interaction - you may need to adjust the therapy.
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- The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
- The article is written: artificial intelligence Kiberis
- Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
- Total analyzed: 169,994,378 possible combinations of drugs and their components were found 412,530 interacting combinations.
- Medicine section: Standard evidence-based medicine
- The date of the last update of the interaction database: 2024-12-19
Category - medicine