Compatibility «Metamizole sodium» and «Dexamethasone»

• Interactions Metamizole sodium with Dexamethasone

  • Dangerous interactions
    • ⓘ Reduce the therapeutic and toxic effects of barbiturates, phenytoin, rifampicin (accelerate metabolism), somatotropin, antacids (reduce absorption), enhance - estrogen-containing oral contraceptives, the risk of arrhythmias and hypokalemia - cardiac glycosides and diuretics, the likelihood of edema and hypertension - sodium-containing drugs or supplements, severe hypokalemia, heart failure and osteoporosis - amphotericin In and carbonic anhydrase inhibitors, the risk of erosive ulcerative lesions and bleeding from the gastrointestinal tract - NSAIDs.
    • ⓘ Prolonged simultaneous use of NSAIDs and GCS should be avoided due to an increased risk of adverse events from the gastrointestinal tract and impaired water-electrolyte balance.
  • Negative interactions
    • ⓘ With drugs that have a high association with plasma proteins (oral hypoglycemic agents, indirect anticoagulants, GCS and indomethacin).
    • ⓘ Sodium metamizole, displacing oral hypoglycemic agents, indirect anticoagulants, GCS and indomethacin from their connection with plasma proteins, enhances their effect.
    • ⓘ The combined use of metamizole with CYP2B6 and/or CYP3A4 substrates, such as bupropion and efavirenz, methadone, cyclosporine, tacrolimus or sertraline, may lead to a decrease in the concentration of these drugs in blood plasma.
    • ⓘ Therefore, caution is recommended when using metamizole and CYP2B6 and/or CYP3A4 substrates simultaneously; assessment of the clinical response and / or concentration of the drug in blood plasma should be accompanied by therapeutic drug monitoring.
    • ⓘ In addition, NSAIDs can mask fever, pain, swelling and other signs and symptoms of infection.
    • ⓘ Glucocorticoids (H02AB) + Amidopyrine, acetylsalicylic acid, butadione, indomethacin and other nonsteroidal anti-inflammatory drugs => Development of edema, increased damaging effect on the mucous membrane of the gastrointestinal tract.
  • Unclear interactions
    • ⓘ With CYP2B6 and/or CYP3A4 substrates.
    • ⓘ Metamizole can induce the metabolizing enzymes CYP2B6 and CYP3A4.
    • ⓘ НПВС.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 169,994,378 possible combinations of drugs and their components were found 412,530 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2024-12-19

Category - medicine