Compatibility «Colecalciferol» and «Vitamin E+Retinol»

• Interactions Colecalciferol with Vitamin E+Retinol

  • Dangerous interactions
    • ⓘ With hypervitaminosis of vitamin D₃, it is possible to enhance the action of cardiac glycosides and increase the risk of arrhythmia due to the development of hypercalcemia (it is advisable to control the concentration of calcium in the blood, electrocardiograms, as well as dose adjustment of cardiac glycoside).
    • ⓘ Long-term use of antacids containing aluminum and magnesium in combination with vitamin D₃ may contribute to an increase in the concentration of aluminum and magnesium in the blood and, as a result, the toxic effect of aluminum on bone tissue and hypermagnesemia in patients with renal insufficiency.
    • ⓘ Concomitant use with other vitamin D analogues increases the risk of vitamin D hypervitaminosis.
  • Negative interactions
    • ⓘ The effect is reduced by diphenin, colestyramine, and vitamin A toxicity.
    • ⓘ Colestyramine, colestipol and mineral oils reduce the absorption of fat‑soluble vitamins in the gastrointestinal tract and require an increase in their dose.
    • ⓘ Ketoconazole can inhibit both biosynthesis and catabolism of 1,25(OH)2‑colecalciferol.
    • ⓘ Vitamin D is an antagonist of drugs used for hypercalcemia: calcitonin, ethidronate, pamidronate, plicamycin, gallium nitrate.
  • No interactions
    • ⓘ Vitamin D₃ does not interact with food.
  • Unclear interactions
    • ⓘ Vitamin E + Colecalciferol analgin and citramon are used together in 141 preparations.
    • ⓘ Antiepileptic drugs (especially phenytoin and phenobarbital, primidone), rifampicin, colestyramine reduce the reabsorption of vitamin D₃.
    • ⓘ Concomitant therapy with glucocorticosteroids may reduce the effectiveness of vitamin D₃.
    • ⓘ Retinol + Colecalciferol analgin and citramon are used together in 102 preparations.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 170,023,408 possible combinations of drugs and their components were found 412,559 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2025-11-20

Category - medicine