Compatibility «Omeprazole» and «Rilpivirine+Tenofovir+Emtricitabine»

• Interactions Omeprazole with Rilpivirine+Tenofovir+Emtricitabine

  • Dangerous interactions
    • ⓘ Proton pump inhibitors (the combination of emtricitabine + rilpivirine + tenofovir should not be used in conjunction with proton pump inhibitors, since concomitant use is likely to develop a significant decrease in the concentration of rilpivirine in plasma (decreased absorption, increased pH of the stomach).
  • Negative interactions
    • ⓘ A decrease in the concentration of rilpivirine in plasma was observed with the simultaneous use of a combination of emtricitabine + rilpivirine + tenofovir with proton pump inhibitors (due to an increase in pH in the stomach), which may lead to a decrease in the therapeutic effect of this combination.
    • ⓘ Omeprazole: reduction of AUC by 14% and max'>C_max by 14%.
    • ⓘ An increase in the pH of the stomach during treatment with omeprazole may alter the absorption of antiretroviral drugs.
    • ⓘ For some antiretroviral drugs, such as atazanavir and nelfinavir, a decrease in serum levels has been reported when used concomitantly with omeprazole.
    • ⓘ For other antiretroviral drugs, such as saquinavir, an increase in its serum level was reported with an increase in AUC by 82%, max'>C_max by 75% and C_min by 106% after repeated administration of the combination saquinavir + ritonavir (1000 + 100 mg) 2 times a day for 15 days with simultaneous administration of omeprazole at 40 mg / day for 11-15 days.
  • No interactions
    • ⓘ Combination with antiretroviral therapy.
  • Unclear interactions
    • ⓘ - Omeprazole/emtricitabine.
    • ⓘ - Omeprazole (20 mg 1 time per day) (lansoprazole², rabeprazole², pantoprazole², esomeprazole²)/rilpivirine¹.
    • ⓘ - Omeprazole/tenofovir disoproxil fumarate.
    • ⓘ Omeprazole has been reported to interact with some antiretroviral drugs.
    • ⓘ There are also some antiretroviral drugs, the level of which in the blood serum has not changed with the simultaneous use of omeprazole.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 169,994,378 possible combinations of drugs and their components were found 412,530 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2024-12-19

Category - medicine