Compatibility «Betamethasone» and «Hydrochlorothiazide»
Between «Betamethasone» and «Hydrochlorothiazide» found 3 dangerous and 4 negative interactions, joint admission is not recommended without consulting a doctor.
Interaction tableCompare |
Hydrochlorothiazide |
✘Betamethasone Analogs | |
✘Hydrochlorothiazide Analogs |
-
Interactions Betamethasone with Hydrochlorothiazide
-
Dangerous interactions
- Therapeutic, toxic effects are reduced by inducers of liver enzymes, enhanced by estrogens and oral contraceptives, the likelihood of arrhythmias and hypokalemia is increased by digitalis glycosides, diuretics (causing potassium deficiency), amphotericin B, carbonic anhydrase inhibitors; the risk of ulcerative erosive lesions or bleeding in the gastrointestinal tract - alcohol and NSAIDs.
- The simultaneous use of GCS and cardiac glycosides increases the risk of arrhythmia or digitalis intoxication (due to hypokalemia).
- It should be used with caution with hypotensive drugs (their effect is potentiated, dose adjustment may be necessary), cardiac glycosides (hypokalemia and hypomagnesemia associated with the action of thiazide diuretics may increase the toxicity of digitalis), amiodarone (its use simultaneously with thiazide diuretics may lead to an increased risk of arrhythmias associated with hypokalemia), hypoglycemic oral medications (their effectiveness decreases, hyperglycemia may develop), corticosteroids, calcitonin (increase potassium excretion), NSAIDs (may weaken the diuretic and hypotensive effects of thiazides), non-depolarizing muscle relaxants (their effect may be enhanced), amantadine (clearance of amantadine may decrease with hydrochlorothiazide, which leads to an increase in plasma concentration of amantadine and possible toxicity), colestyramine (reduces absorption of hydrochlorothiazide), ethanol, barbiturates and narcotic analgesics, which enhance the effect of orthostatic hypotension.
-
Negative interactions
- It weakens the hypoglycemic activity of antidiabetic drugs and insulin, natriuretic and diuretic - diuretics, the activity of vaccines (due to a decrease in antibody production); anticoagulation - derivatives of coumarin and indanedione, heparin, streptokinase and urokinase.
- With the combined use of GCS and potassium-releasing diuretics, the likelihood of hypokalemia increases.
- Glucocorticoids (H02AB), mineralocorticoids (H02AA) + Diuretics that enhance the excretion of potassium ions (dichlothiazide, etc.), cardiac glycosides, amphotericin B => Hypokalemia syndrome; cardiac arrhythmia, muscle weakness, etc.
- Diuretics, Diacarb, dichlotiazide, furosemide, ethacric acid + Amphotericin B, glucocorticoids, corticotropin, cardiac glycosides, laxatives and other agents that promote the excretion of potassium from the body => Cardiac dysfunction, muscle weakness and other manifestations of hypokalemia.
-
Dangerous interactions
Decoding the colors of interactions and contraindications
Dangerous | — | a pronounced negative interaction or contraindication. |
Negative | — | negative interaction or side effect that may reduce effectiveness. |
Positive | — | the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug. |
No | — | the drugs do NOT interact, which is separately indicated in the instructions. |
Unclear | — | the system failed to pre-assess the danger. |
Video instruction
Additional information
- Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
- Why do I need to
- Avoid dangerous prescriptions for your patients.
- Check the contraindications.
- Evaluate the safety of therapy in the treatment of children.
- See the compatibility of drugs with alcohol (enter it as a drug).
- Point the doctor to the found interaction - you may need to adjust the therapy.
- Do you need an API for interactions/drug analogues for your project? Write to us.
- The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
- The article is written: artificial intelligence Kiberis
- Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
- Total analyzed: 169,996,192 possible combinations of drugs and their components were found 412,532 interacting combinations.
- Medicine section: Standard evidence-based medicine
- The date of the last update of the interaction database: 2025-01-09
Category - medicine