Compatibility «Amlodipine» and «Atenolol+Chlortalidone»

• Interactions Amlodipine with Atenolol+Chlortalidone

  • Dangerous interactions
    • ⓘ With the simultaneous use of beta‑blockers with nonhydropyridine BMCC, such as verapamil and diltiazem, the negative effect on myocardial contractility and atrioventricular conduction increases, which can lead to severe arterial hypotension, atrioventricular blockade and cardiac arrest.
    • ⓘ Calcium channel blockers(C08) + Drugs that cause hypokalemia; Glucocorticosteroids (C03A, A01AB04,J02AA01,H02,D07 => Increases the likelihood of ventricular tachycardia and ventricular fibrillation. (A dangerous combination, it is necessary to eliminate hypokalemia before use).
  • Negative interactions
    • ⓘ The use of beta-blockers in combination with blockers of 'slow' calcium channels that have a negative inotropic effect, for example, verapamil, diltiazem, can lead to an increase in this effect, especially in patients with reduced myocardial contractility and/ or with impaired sinoatrial or atrioventricular conduction.
    • ⓘ The blocker of 'slow' calcium channels should not be used intravenously for 48 hours after the withdrawal of the beta-blocker.
    • ⓘ Amlodipine can be safely used to treat hypertension together with thiazide diuretics, beta-blockers or ACE inhibitors.
    • ⓘ Other antihypertensive and antianginal drugs.
  • No interactions
    • ⓘ In patients with stable angina pectoris, amlodipine can be used in combination with other antianginal agents, for example, with prolonged or short-acting nitrates beta-blockers.
  • Positive interactions
    • ⓘ It is possible to enhance the antianginal and antihypertensive effects of BMCC when combined with thiazide and loop diuretics, ACE inhibitors, beta-blockers and nitrates.
    • ⓘ Enhances the effect of curare-like muscle relaxants and antihypertensive drugs (in pm guanethidine, methyldopa, beta-blockers, vasodilators, BCC, MAO inhibitors).
  • Unclear interactions
    • ⓘ Amlodipine + Atenolol analgin and citramon are used together in Tenochek.
    • ⓘ Blockers of 'slow' calcium channels (BMCC).

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 169,994,378 possible combinations of drugs and their components were found 412,530 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2024-12-19

Category - medicine