Compatibility «Phenobarbital» and «Gestodene+Ethinylestradiol»

• Interactions Phenobarbital with Gestodene+Ethinylestradiol

  • Negative interactions
    • ⓘ Steroid hormones and their analogues Androgens, anabolic steroids, progestogens, estrogens, glucocorticoids, mineralocorticoids, steroid contraceptives + Butadione, diphenin, rifampicin, phenobarbital => Weakening of the pharmacotherapeutic effects of group I drugs.
    • ⓘ Enhances the metabolism of drugs biotransforming in the liver (due to the activation of microsomal oxidation enzymes) and reduces the effect of: indirect anticoagulants, PM warfarin, acenocumarol, phenindione, etc; (lowers the level of anticoagulants in the blood, with simultaneous administration, periodic monitoring of PV is necessary to correct doses of anticoagulants), corticosteroids, digitalis preparations, chloramphenicol, metronidazole, doxycycline (reduces T _1/2 doxycycline, this effect can persist for 2 weeks after discontinuation of barbiturate), tricyclic antidepressants, estrogens, salicylates, paracetamol, etc.; Phenobarbital reduces the absorption of griseofulvin and its level in the blood.
  • Unclear interactions
    • ⓘ Estrogens -.
    • ⓘ - substances that induce microsomal liver enzymes, such as rifampicin, rifabutin, barbiturates, anticonvulsants (e.g. carbamazepine, phenytoin or topiramate), griseofulvin, roxaclon, primidone, modafinil, some protease inhibitors (e.g. ritonavir) and St. John's wort preparations;.
    • ⓘ (mainly the CYP3A4 isoenzyme).

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 169,994,378 possible combinations of drugs and their components were found 412,530 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2024-12-19

Category - medicine