Compatibility «Phenobarbital» and «Clonazepam»

• Interactions Phenobarbital with Clonazepam

  • Dangerous interactions
    • ⓘ When used simultaneously with other drugs that depress the central nervous system (in pm sedatives, hypnotics, some antihistamines, anxiolytics), and alcohol, an additive depressive effect is possible.
    • ⓘ The depressing effect on the central nervous system is enhanced by alcohol, narcotic analgesics, hypnotics (in pm barbiturates), other anxiolytics and anticonvulsants, neuroleptics (in pm phenothiazines, thioxanthenes and butyrophenones), MAO inhibitors, tricyclic antidepressants.
    • ⓘ When using clonazepam in combination with other antiepileptic drugs, side effects such as sedation and apathy, toxicity may be more pronounced, especially when combined with hydantoin, phenobarbital and their combinations.
  • Negative interactions
    • ⓘ The same effects are observed when taken simultaneously with other CNS depressants.
    • ⓘ Phenytoin, carbamazepine, phenobarbital accelerate the metabolism of clonazepam, reduce its blood level by 30% and weaken the effect.
    • ⓘ Antiepileptic drugs such as phenytoin, phenobarbital, carbamazepine and valproate can induce clonazepam metabolism, providing higher clearance and lower plasma concentrations of clonazepam in combination treatment.
  • Positive interactions
    • ⓘ The simultaneous use of clonazepam and other centrally acting drugs, for example, other anticonvulsants (antiepileptic) drugs, anesthetics, hypnotics, psychotropic drugs and some analgesics, as well as muscle relaxants, can lead to mutual potentiation of drug effects.
  • Unclear interactions
    • ⓘ Anxiolytics and sleeping pills - clonazepam.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
• Why do I need to
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 169,994,378 possible combinations of drugs and their components were found 412,530 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2024-12-19

Category - medicine