Compatibility «Tramadol» and «Morphine sulfate»

• Interactions Tramadol with Morphine sulfate

  • Dangerous interactions
    • ⓘ Buprenorphine (in pm, previous therapy) reduces the effect of other opioid analgesics; against the background of high doses of mu-opioid receptor agonists, it reduces respiratory depression, and against the background of low doses of mu- or kappa-opioid receptor agonists, it increases.
    • ⓘ When taken simultaneously with beta-blockers, it is possible to increase the depressive effect on the central nervous system, with dopamine - a decrease in the analgesic effect of morphine, with cimetidine - increased respiratory depression, with other opioid analgesics - central nervous system depression, respiration, decreased blood pressure.
    • ⓘ Naloxone reduces the effect of opioid analgesics, as well as the respiratory depression and central nervous system caused by them;.
  • Negative interactions
    • ⓘ accelerates the appearance of symptoms of the 'withdrawal' syndrome upon discontinuation of mu-opioid receptor agonists against the background of drug dependence, with their sudden withdrawal partially reduces the severity of these symptoms.
    • ⓘ With systematic administration of barbiturates, especially phenobarbital, there is a possibility of reducing the severity of the analgesic effect of narcotic analgesics, stimulates the development of cross-tolerance.
    • ⓘ Tramadol and Morphine belong to the same pharmaceutical group: Opioid narcotic analgesics.
    • ⓘ Tramadol and Morphine sulfate belong to the same pharmaceutical group: Opioid narcotic analgesics.
  • No interactions
    • ⓘ Reduces the effect of opioid analgesics (analgesic, antidiarrheal, antitussive); does not affect the symptoms caused by a histamine reaction.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 170,023,408 possible combinations of drugs and their components were found 412,559 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2025-11-20

Category - medicine