Compatibility «Thioridazine» and «Melatonin»

• Interactions Thioridazine with Melatonin

  • Dangerous interactions
    • ⓘ When used in combination with tricyclic antidepressants, maprotilin, MAO inhibitors, antihistamines, it is possible to prolong and enhance sedative and anticholinergic effects, with thiazide diuretics - increased hyponatremia, with Li⁺ drugs - decreased absorption of phenothiazine in the gastrointestinal tract, increased rate of excretion of Li⁺ kidney damage, increased severity of extrapyramidal disorders (early signs of lithium intoxication - nausea and vomiting - may be masked by the antiemetic effect of thioridazine).
    • ⓘ Hypnotics, Barbiturates, glutetimide, nitrazepam, etc. + Antihistamines with a sedative component (diphedrol, diprazine, suprastin), antihypertensive agents (clofelin, reserpine), neuroleptics (aminazine, haloperidol), tranquilizers (sibazone) => Increased hypnotic effect up to toxic.
  • Negative interactions
    • ⓘ However, the combined use with melatonin led to an increased sense of calm and caused difficulties in performing tasks compared with taking imipramine alone and to an increased feeling of dizziness compared with taking thioridazine alone.
  • Positive interactions
    • ⓘ It enhances the effect of sleeping pills, analgesics, anesthetics and alcohol.
  • Unclear interactions
    • ⓘ Melatonin was used in clinical studies simultaneously with thioridazine and imipramine, active substances that affect the central nervous system.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
• Why do I need to
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 169,994,378 possible combinations of drugs and their components were found 412,530 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2024-12-19

Category - medicine