Compatibility «Carbamazepine» and «Clozapine»
Between «Carbamazepine» and «Clozapine» found 3 dangerous and 2 negative interactions, joint admission is not recommended without consulting a doctor.
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Interactions Carbamazepine with Clozapine
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Dangerous interactions
- Clozapine is incompatible with drugs that cause agranulocytosis: carbamazepine, co-trimoxazole, chloramphenicol, penicillamine, sulfonamides, pyrazolone analgesics.
- Clozapine can enhance the central action of ethanol, MAO inhibitors and drugs that depress the central nervous system (such as drugs for anesthesia, H1‑histamine receptor blockers and benzodiazepines).
- Since clozapine can lower the seizure threshold, it may be necessary to adjust the dose of antiepileptic drugs.
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Negative interactions
- Drugs that are inducers of the cytochrome P450 isoenzyme CYP3A4 (for example, carbamazepine or rifampicin) can help reduce the concentration of clozapine in blood plasma.
- When simultaneous treatment with carbamazepine was discontinued, an increase in clozapine in blood plasma was noted.
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Unclear interactions
- - antipsychotic drugs (neuroleptics): olanzapine;.
- - antipsychotic drugs (antipsychotics): clozapine, haloperidol, bromperidol, olanzapine, quetiapine, risperidone, ziprasidone, aripiprazole, paliperidone;.
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Dangerous interactions
Decoding the colors of interactions and contraindications
| Dangerous | — | a pronounced negative interaction or contraindication. |
| Negative | — | negative interaction or side effect that may reduce effectiveness. |
| Positive | — | the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug. |
| No | — | the drugs do NOT interact, which is separately indicated in the instructions. |
| Unclear | — | the system failed to pre-assess the danger. |
Video instruction
Additional information
- Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
- Why do I need to
- Avoid dangerous prescriptions for your patients.
- Check the contraindications.
- Evaluate the safety of therapy in the treatment of children.
- See the compatibility of drugs with alcohol (enter it as a drug).
- Point the doctor to the found interaction - you may need to adjust the therapy.
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- The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
- The article is written: artificial intelligence Kiberis
- Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
- Total analyzed: 169,994,378 possible combinations of drugs and their components were found 412,530 interacting combinations.
- Medicine section: Standard evidence-based medicine
- The date of the last update of the interaction database: 2024-12-19
Category - medicine