Compatibility «Fluoxetine» and «Dapoxetine»

• Interactions Fluoxetine with Dapoxetine

  • Dangerous interactions
    • ⓘ In patients receiving both SSRIs and an MAO inhibitor, serious, sometimes fatal reactions were described, including hyperthermia, rigidity, myoclonus, instability of the autonomic system with possible rapid fluctuations in vital signs, as well as a change in mental state, in pm strong arousal, progressing to delirium and coma.
    • ⓘ Dapoxetine should not be taken simultaneously with other SSRIs, MAO inhibitors and other serotonergic drugs and within 14 days after discontinuation of these drugs.
  • Negative interactions
    • ⓘ These reactions were also observed in patients who had recently stopped taking SSRIs and started treatment with an MAO inhibitor.
    • ⓘ As in the case of SSRIs, taking dapoxetine simultaneously with serotonergic drugs (including MAO inhibitors, L-tryptophan, triptans, tramadol, linezolid, SSRIs, serotonin and norepinephrine uptake inhibitors, lithium and St. John's wort (Hypericum perforatum) preparations may increase the frequency of serotonergic side effects.
  • No interactions
    • ⓘ Data on the combined use of SSRIs and MAO inhibitors in animals suggest that these drugs can synergistically increase blood pressure and cause behavioral arousal.
  • Unclear interactions
    • ⓘ Fluoxetine intake at a dose of 60 mg / day for 7 days increased from _max and AUC_0-∞ dapoxetine (60 mg once) by 50 and 88%, respectively.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
• Why do I need to
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 170,027,037 possible combinations of drugs and their components were found 412,563 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2026-01-01

Category - medicine