Compatibility «Fluoxetine» and «Clomipramine»

• Interactions Fluoxetine with Clomipramine

  • Negative interactions
    • ⓘ The simultaneous use of fluoxetine and other drugs metabolized by CYP2D6, including some antidepressants (e.g. tricyclic antidepressants), neuroleptics (e.g. phenothiazines and most atypical neuroleptics) and antiarrhythmic drugs (e.g. propafenone, flecainide), should be approached with caution.
    • ⓘ Drugs with a narrow therapeutic index (for example, flecainide, propafenone, vinblastine and tricyclic antidepressants) are of the greatest concern.
    • ⓘ Thus, it may be necessary to reduce the dose of tricyclic antidepressants and temporarily monitor the concentration of tricyclic antidepressants in plasma with simultaneous use of fluoxetine or recent discontinuation of administration (see 'Precautions').
    • ⓘ Fluoxetine and Clomipramine belong to the same pharmaceutical group: Antidepressants.
    • ⓘ With the simultaneous use of clomipramine with SSRIs or serotonin and norepinephrine reuptake inhibitors (norepinephrine), tricyclic antidepressants and lithium preparations, serotonin syndrome may develop.
    • ⓘ Fluoxetine and fluvoxamine increase the concentration of clomipramine in plasma (it may be necessary to reduce the dose of clomipramine by 50%).
    • ⓘ Selective serotonin reuptake inhibitors: the combined use of Clomipramine with these drugs may lead to an increased effect on the serotonin system.
    • ⓘ In addition, fluoxetine and fluvoxamine can increase the concentration of Clomipramine in blood plasma, which is accompanied by the development of appropriate adverse reactions.
  • Positive interactions
    • ⓘ If it is necessary to prescribe fluoxetine, it is recommended to take a two- to three-week break between the use of clomipramine and fluoxetine.
  • Unclear interactions
    • ⓘ Thus, this study suggests that drugs that inhibit CYP2D6, such as some SSRIs, including fluoxetine, cause an increase in plasma thioridazine levels.
    • ⓘ Tricyclic antidepressants.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 169,994,378 possible combinations of drugs and their components were found 412,530 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2024-12-19

Category - medicine