Compatibility «Estarizol» and «Клозапин-Фармаплант»

• Interactions Estarizol with Клозапин-Фармаплант

  • Dangerous interactions
    • ⓘ Clozapine should not be used simultaneously with long-acting antipsychotic drugs in the form of depots, which have a potential myelosuppressive effect and cannot be quickly eliminated from the body if necessary, for example, when neutropenia occurs.
  • Negative interactions
    • ⓘ When using clozapine with agents that cause myelodepression, the depressive effect on bone marrow hematopoiesis increases.
    • ⓘ Concomitant use with drugs that inhibit the activity of cytochrome CYP450 isoenzymes, such as cimetidine (inhibitor of CYP1A2, 3A4, and 2D6 isoenzymes) or erythromycin (inhibitor of CYP3A4 isoenzyme), clarithromycin, azithromycin, fluvoxamine (1A2), perazine (1A2) or ciprofloxacin (1A2) and hormonal oral contraceptives (1A2, 3A4, 2C19) with clozapine in high doses led to an increase in the concentration of clozapine in blood plasma and the occurrence of adverse reactions.
    • ⓘ In patients receiving clozapine simultaneously with fluvoxamine, an inhibitor of CYP3A4 and CYP1A2 isoenzymes, an increase in the concentration of the former in blood plasma (up to 10 times) or other selective serotonin reuptake inhibitors, such as paroxetine (inhibitor of CYP1A2 and CYP2D6 isoenzymes), sertraline (inhibitor of CYP2C8/9 and CYP2D6 isoenzymes), fluoxetine ( inhibitor CYP2D6 isoenzyme, increased up to 2 times) or citalopram (possibly a weak inhibitor of the CYP1A2 isoenzyme, which most likely has the weakest ability among all serotonin reuptake inhibitors, causing the development of clinically significant interaction).
    • ⓘ Powerful inhibitors/inducers of the CYP3A4 isoenzyme, such as azole antimycotics and protease inhibitors, can potentially alter the concentration of clozapine in blood plasma, but so far such interactions have not been described.
    • ⓘ Drugs that are inducers of the cytochrome P_{450 isoenzyme CYP3A4 (for example, carbamazepine or rifampicin) can help reduce the concentration of clozapine in blood plasma.}
    • ⓘ Omeprazole is an inducer of the CYP1A2 and CYP3A4 isoenzyme, as well as an inhibitor of the CYP2C19 isoenzyme.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 170,032,480 possible combinations of drugs and their components were found 412,568 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2026-03-05

Category - medicine